Intramyocardial gene silencing by interfering RNA

RNAi is a widely used methodology for gene silencing. The action mechanism of siRNA molecules has been well studiedin recent years, and the technique has been optimized in terms of safety and effectiveness. Cardiovascular diseases have a high incidence in the current population, and despite of the e...

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Detalles Bibliográficos
Autores principales: Brea, María Soledad, Morgan, Patricio Eduardo, Pérez, Néstor Gustavo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2017
Materias:
Ciencias Médicas
SiRNA
Heart
Lentivirus
Cardiomyocyte
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/104402
http://hdl.handle.net/11336/49492
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-104402
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
SiRNA
Heart
Lentivirus
Cardiomyocyte
spellingShingle Ciencias Médicas
SiRNA
Heart
Lentivirus
Cardiomyocyte
Brea, María Soledad
Morgan, Patricio Eduardo
Pérez, Néstor Gustavo
Intramyocardial gene silencing by interfering RNA
topic_facet Ciencias Médicas
SiRNA
Heart
Lentivirus
Cardiomyocyte
description RNAi is a widely used methodology for gene silencing. The action mechanism of siRNA molecules has been well studiedin recent years, and the technique has been optimized in terms of safety and effectiveness. Cardiovascular diseases have a high incidence in the current population, and despite of the extensive research, safe and efficient therapeutics have notyet been found, which is reflected by 17.1 million people who die each year for this cause. In this context, siRNAs arebeing considered a therapeutic tool to regulate the expression of genes involved in the generation of these pathologies.The efficacy of siRNAs entry to cardiomyocytes, the safety of the delivery process and the degree of silencing achievedare main aspects before consider it as a cardiovascular disease therapy. Presently, we will give a brief outline of thecurrent understanding of the RNAi mechanism and the delivery system to the heart. We describe the use of lentivirus fora functional silencing of cardiac proteins in the study of a pathophysiological process, the slow force response to cardiac stretch.
format Articulo
Articulo
author Brea, María Soledad
Morgan, Patricio Eduardo
Pérez, Néstor Gustavo
author_facet Brea, María Soledad
Morgan, Patricio Eduardo
Pérez, Néstor Gustavo
author_sort Brea, María Soledad
title Intramyocardial gene silencing by interfering RNA
title_short Intramyocardial gene silencing by interfering RNA
title_full Intramyocardial gene silencing by interfering RNA
title_fullStr Intramyocardial gene silencing by interfering RNA
title_full_unstemmed Intramyocardial gene silencing by interfering RNA
title_sort intramyocardial gene silencing by interfering rna
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/104402
http://hdl.handle.net/11336/49492
work_keys_str_mv AT breamariasoledad intramyocardialgenesilencingbyinterferingrna
AT morganpatricioeduardo intramyocardialgenesilencingbyinterferingrna
AT pereznestorgustavo intramyocardialgenesilencingbyinterferingrna
bdutipo_str Repositorios
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