Regenerative medicine for the aging brain

In the central nervous system, cholinergic and dopaminergic (DA) neurons are among the cells most susceptible to the deleterious effects of age. Thus, the basal forebrain cholinergic system is known to undergo moderate neurodegenerative changes during normal aging as well as severe atrophy in Alzhei...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: López León, Micaela, Reggiani, Paula Cecilia, Hereñú, Claudia Beatriz, Goya, Rodolfo Gustavo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2014
Materias:
Biología
Ciencias Médicas
Brain aging
Neurodegeneration
Regenerative medicine
Cell reprogramming
Direct reprogramming
iPSCs
Transdifferentiation
Enfermedad de Parkinson
Enfermedad de Alzheimer
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/104376
http://hdl.handle.net/11336/34040
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-104376
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Ciencias Médicas
Brain aging
Neurodegeneration
Regenerative medicine
Cell reprogramming
Direct reprogramming
iPSCs
Transdifferentiation
Enfermedad de Parkinson
Enfermedad de Alzheimer
spellingShingle Biología
Ciencias Médicas
Brain aging
Neurodegeneration
Regenerative medicine
Cell reprogramming
Direct reprogramming
iPSCs
Transdifferentiation
Enfermedad de Parkinson
Enfermedad de Alzheimer
López León, Micaela
Reggiani, Paula Cecilia
Hereñú, Claudia Beatriz
Goya, Rodolfo Gustavo
Regenerative medicine for the aging brain
topic_facet Biología
Ciencias Médicas
Brain aging
Neurodegeneration
Regenerative medicine
Cell reprogramming
Direct reprogramming
iPSCs
Transdifferentiation
Enfermedad de Parkinson
Enfermedad de Alzheimer
description In the central nervous system, cholinergic and dopaminergic (DA) neurons are among the cells most susceptible to the deleterious effects of age. Thus, the basal forebrain cholinergic system is known to undergo moderate neurodegenerative changes during normal aging as well as severe atrophy in Alzheimer’s disease (AD). Parkinson’s disease (PD), a degeneration of nigro-striatal DA neurons is the most conspicuous reflection of the vulnerability of DA neurons to age. In this context, cell reprogramming offers novel therapeutic possibilities for the treatment of these devastating diseases. In effect, the generation of induced pluripotent stem cells (iPSCs) from somatic cells demonstrated that adult mammalian cells can be reprogrammed to a pluripotent state by the overexpression of a few embryonic transcription factors (TF). This discovery fundamentally widened the research horizon in the fields of disease modeling and regenerative medicine. Although it is possible to re-differentiate iPSCs to specific somatic cell types, the tumorigenic potential of contaminating iPSCs that failed to differentiate, increases the risk for clinical application of somatic cells generated by this procedure. Therefore, reprogramming approaches that bypass the pluripotent stem cell state are being explored. A method called lineage reprogramming has been recently documented. It consists of the direct conversion of one adult cell type into another by transgenic expression of multiple lineage-specific TF or microRNAs. Another approach, termed direct reprogramming, features several advantages such as the use of universal TF system and the ability to generate a rejuvenated multipotent progenitor cell population, able to differentiate into specific cell types in response to a specific differentiation factors. These novel approaches offer a new promise for the treatment of pathologies associated with the loss of specific cell types as for instance, nigral DA neurons (in PD) or basal forebrain cholinergic neurons in the early stages of AD. The above topics are reviewed here.
format Articulo
Articulo
author López León, Micaela
Reggiani, Paula Cecilia
Hereñú, Claudia Beatriz
Goya, Rodolfo Gustavo
author_facet López León, Micaela
Reggiani, Paula Cecilia
Hereñú, Claudia Beatriz
Goya, Rodolfo Gustavo
author_sort López León, Micaela
title Regenerative medicine for the aging brain
title_short Regenerative medicine for the aging brain
title_full Regenerative medicine for the aging brain
title_fullStr Regenerative medicine for the aging brain
title_full_unstemmed Regenerative medicine for the aging brain
title_sort regenerative medicine for the aging brain
publishDate 2014
url http://sedici.unlp.edu.ar/handle/10915/104376
http://hdl.handle.net/11336/34040
work_keys_str_mv AT lopezleonmicaela regenerativemedicinefortheagingbrain
AT reggianipaulacecilia regenerativemedicinefortheagingbrain
AT herenuclaudiabeatriz regenerativemedicinefortheagingbrain
AT goyarodolfogustavo regenerativemedicinefortheagingbrain
bdutipo_str Repositorios
_version_ 1764820442188611585

Ejemplares similares