Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation

Arsenic (As) is one of the most toxic naturally occurring contaminants in the environment. The major source of human exposure to inorganic As (iAs) is through contaminated drinking water. Although both genotoxicity and carcinogenicity derived from this metalloid have been thoroughly studied, the eff...

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Autores principales: Gumilar, Fernanda Andrea, Lencinas, Ileana, Bras, Cristina Liliana, Giannuzzi, Leda, Minetti, Alejandra
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2015
Materias:
Química
Biología
Arsenic
Development exposure
Sensory-motor reflexes
Functional observational battery
Locomotor activity
Rat
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/104347
http://hdl.handle.net/11336/7590
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-104347
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Biología
Arsenic
Development exposure
Sensory-motor reflexes
Functional observational battery
Locomotor activity
Rat
spellingShingle Química
Biología
Arsenic
Development exposure
Sensory-motor reflexes
Functional observational battery
Locomotor activity
Rat
Gumilar, Fernanda Andrea
Lencinas, Ileana
Bras, Cristina Liliana
Giannuzzi, Leda
Minetti, Alejandra
Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation
topic_facet Química
Biología
Arsenic
Development exposure
Sensory-motor reflexes
Functional observational battery
Locomotor activity
Rat
description Arsenic (As) is one of the most toxic naturally occurring contaminants in the environment. The major source of human exposure to inorganic As (iAs) is through contaminated drinking water. Although both genotoxicity and carcinogenicity derived from this metalloid have been thoroughly studied, the effects of iAs on the development and function of the central nervous system (CNS) have received less attention and only a few studies have focused on neurobehavioral effects. Thus, in order to characterize developmental and behavioral alterations induced by iAs exposure, pregnant Wistar rats were exposed to 0.05 and 0.10 mg/L iAs through drinking water during gestation and lactation. Sensory-motor reflexes in each pup were analyzed and the postnatal day when righting reflex, cliff aversion and negative geotaxis were observed was recorded. Functional Observational Battery (FOB) and locomotor activity in an open field were assessed in 90-day-old offspring. Results show that rats exposed to low iAs concentrations through drinking water during early development evidence a delay in the development of sensory-motor reflexes. Both FOB procedure and open-field tests showed a decrease in locomotor activity in adult rats. This study reveals that exposure to the above-mentioned iAs concentrations produces dysfunction in the CNS mechanisms whose role is to regulate motor and sensory development and locomotor activity.
format Articulo
Preprint
author Gumilar, Fernanda Andrea
Lencinas, Ileana
Bras, Cristina Liliana
Giannuzzi, Leda
Minetti, Alejandra
author_facet Gumilar, Fernanda Andrea
Lencinas, Ileana
Bras, Cristina Liliana
Giannuzzi, Leda
Minetti, Alejandra
author_sort Gumilar, Fernanda Andrea
title Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation
title_short Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation
title_full Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation
title_fullStr Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation
title_full_unstemmed Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation
title_sort locomotor activity and sensory-motor developmental alterations in rat offspring exposed to arsenic prenatally and via lactation
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/104347
http://hdl.handle.net/11336/7590
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