The role of Galectin-1 and Galectin-3 in the mucosal immune response to <i>Citrobacter rodentium</i> infection

Despite their abundance at gastrointestinal sites, little is known about the role of galectins in gut immune responses. We have therefore investigated the <i>Citrobacter rodentium</i> model of colonic infection and inflammation in Galectin-1 or Galectin- 3 null mice. Gal-3 null mice show...

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Autores principales:	Curciarello, Renata, Steele, Alison, Cooper, Dianne, Macdonald, Thomas T., Kruidenier, Lauren, Takahiro, Kudo
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2014
Materias:	Biología Ciencias Naturales Ciencias Exactas Galectins Gastrointestinal tract Citrobacter rodentium infection Galectin deficient mice Mucosa
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/104084 http://hdl.handle.net/11336/10704 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107933
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-104084
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Biología Ciencias Naturales Ciencias Exactas Galectins Gastrointestinal tract Citrobacter rodentium infection Galectin deficient mice Mucosa
spellingShingle	Biología Ciencias Naturales Ciencias Exactas Galectins Gastrointestinal tract Citrobacter rodentium infection Galectin deficient mice Mucosa Curciarello, Renata Steele, Alison Cooper, Dianne Macdonald, Thomas T. Kruidenier, Lauren Takahiro, Kudo The role of Galectin-1 and Galectin-3 in the mucosal immune response to <i>Citrobacter rodentium</i> infection
topic_facet	Biología Ciencias Naturales Ciencias Exactas Galectins Gastrointestinal tract Citrobacter rodentium infection Galectin deficient mice Mucosa
description	Despite their abundance at gastrointestinal sites, little is known about the role of galectins in gut immune responses. We have therefore investigated the <i>Citrobacter rodentium</i> model of colonic infection and inflammation in Galectin-1 or Galectin- 3 null mice. Gal-3 null mice showed a slight delay in colonisation after inoculation with <i>C. rodentium</i> and a slight delay in resolution of infection, associated with delayed T cell, macrophage and dendritic cell infiltration into the gut mucosa. However, Gal-1 null mice also demonstrated reduced T cell and macrophage responses to infection. Despite the reduced T cell and macrophage response in Gal-1 null mice, there was no effect on <i>C. rodentium</i> infection kinetics and pathology. Overall, Gal-1 and Gal-3 play only a minor role in immunity to a gut bacterial pathogen.
format	Articulo Articulo
author	Curciarello, Renata Steele, Alison Cooper, Dianne Macdonald, Thomas T. Kruidenier, Lauren Takahiro, Kudo
author_facet	Curciarello, Renata Steele, Alison Cooper, Dianne Macdonald, Thomas T. Kruidenier, Lauren Takahiro, Kudo
author_sort	Curciarello, Renata
title	The role of Galectin-1 and Galectin-3 in the mucosal immune response to <i>Citrobacter rodentium</i> infection
title_short	The role of Galectin-1 and Galectin-3 in the mucosal immune response to <i>Citrobacter rodentium</i> infection
title_full	The role of Galectin-1 and Galectin-3 in the mucosal immune response to <i>Citrobacter rodentium</i> infection
title_fullStr	The role of Galectin-1 and Galectin-3 in the mucosal immune response to <i>Citrobacter rodentium</i> infection
title_full_unstemmed	The role of Galectin-1 and Galectin-3 in the mucosal immune response to <i>Citrobacter rodentium</i> infection
title_sort	role of galectin-1 and galectin-3 in the mucosal immune response to <i>citrobacter rodentium</i> infection
publishDate	2014
url	http://sedici.unlp.edu.ar/handle/10915/104084 http://hdl.handle.net/11336/10704 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107933
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The role of Galectin-1 and Galectin-3 in the mucosal immune response to <i>Citrobacter rodentium</i> infection

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