Circadian rhythm of VEGF expression in the liver of hepatectomized tumor bearing mice

In this study we analyzed VEGF-C expression in regenerating liver (after partial hepactectomy) of ES2 hepatocellular carcinoma bearing mice, throughout one complete circadian cycle. The animals were sacrificed every 4 h throughout one complete circadian cycle from 26 to 50 h post-hepatectomy. Tumor...

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Autores principales: Andrini, Laura Beatriz, García, Marcela Nilda, Inda, Ana María, Errecalde, Ana Lía
Formato: Articulo
Lenguaje:Inglés
Publicado: 2009
Materias:
Ciencias Médicas
Mouse
Liver
VEGF
Hepatocellular carcinoma
Circadian rhythms
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/103915
https://www.tandfonline.com/doi/pdf/10.1080/09291010902863347
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-103915
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Mouse
Liver
VEGF
Hepatocellular carcinoma
Circadian rhythms
spellingShingle Ciencias Médicas
Mouse
Liver
VEGF
Hepatocellular carcinoma
Circadian rhythms
Andrini, Laura Beatriz
García, Marcela Nilda
Inda, Ana María
Errecalde, Ana Lía
Circadian rhythm of VEGF expression in the liver of hepatectomized tumor bearing mice
topic_facet Ciencias Médicas
Mouse
Liver
VEGF
Hepatocellular carcinoma
Circadian rhythms
description In this study we analyzed VEGF-C expression in regenerating liver (after partial hepactectomy) of ES2 hepatocellular carcinoma bearing mice, throughout one complete circadian cycle. The animals were sacrificed every 4 h throughout one complete circadian cycle from 26 to 50 h post-hepatectomy. Tumor samples were processed for immunohistochemistry. The expression of VEGF was assessed according to the percentage of immunoreactive cells in a total of 1000 cells (quantitative analysis). The results show that controls and tumor bearing mice have statistical differences at all analysed time points, but the maximun value of VEGF expression of treated animals is significantly higher (p < 0.01) than the control group. We can conclude that when a partial hepatectomy is made with the purpose of eradicating a hepatic tumor, the presence of possible metastasis could release factors related with cellular proliferation that could increase the possibilities of tumoral recidives.
format Articulo
Articulo
author Andrini, Laura Beatriz
García, Marcela Nilda
Inda, Ana María
Errecalde, Ana Lía
author_facet Andrini, Laura Beatriz
García, Marcela Nilda
Inda, Ana María
Errecalde, Ana Lía
author_sort Andrini, Laura Beatriz
title Circadian rhythm of VEGF expression in the liver of hepatectomized tumor bearing mice
title_short Circadian rhythm of VEGF expression in the liver of hepatectomized tumor bearing mice
title_full Circadian rhythm of VEGF expression in the liver of hepatectomized tumor bearing mice
title_fullStr Circadian rhythm of VEGF expression in the liver of hepatectomized tumor bearing mice
title_full_unstemmed Circadian rhythm of VEGF expression in the liver of hepatectomized tumor bearing mice
title_sort circadian rhythm of vegf expression in the liver of hepatectomized tumor bearing mice
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/103915
https://www.tandfonline.com/doi/pdf/10.1080/09291010902863347
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