Apigenin oxidovanadium(IV) cation interactions : Synthesis, spectral, bovine serum albumin binding, antioxidant and anticancer studies

Continuing and expanding our previous work on flavonoid oxidovanadium(IV) (VO) metal complexes as possible anti-cancer agents, the VOapigenin compound was synthesized and characterized. An “acetylacetone-like” coordination through the C=O and O moieties of the ligand to the metal center with one api...

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Autores principales:	Martínez Medina, Juan José, Naso, Luciana, Pérez, Ana L., Rizzi, Alberto, Okulik, Nora Beatriz, Williams, Patricia Ana María
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2017
Materias:	Química Oxidovanadim (IV) Apigenin Cáncer Oxidative stress Bovine serum albumin
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/103790 https://www.sciencedirect.com/science/article/abs/pii/S1010603017303945?via%3Dihub
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-103790
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Química Oxidovanadim (IV) Apigenin Cáncer Oxidative stress Bovine serum albumin
spellingShingle	Química Oxidovanadim (IV) Apigenin Cáncer Oxidative stress Bovine serum albumin Martínez Medina, Juan José Naso, Luciana Pérez, Ana L. Rizzi, Alberto Okulik, Nora Beatriz Williams, Patricia Ana María Apigenin oxidovanadium(IV) cation interactions : Synthesis, spectral, bovine serum albumin binding, antioxidant and anticancer studies
topic_facet	Química Oxidovanadim (IV) Apigenin Cáncer Oxidative stress Bovine serum albumin
description	Continuing and expanding our previous work on flavonoid oxidovanadium(IV) (VO) metal complexes as possible anti-cancer agents, the VOapigenin compound was synthesized and characterized. An “acetylacetone-like” coordination through the C=O and O moieties of the ligand to the metal center with one apigenin ligand per metal ion was assumed using different spectroscopies and elemental analysis as well as thermal measurements. The vibrational experimental spectrum of VOapigenin was supported by theoretical calculations. According to the structure of the flavonoid it exerted mild antioxidant properties that were enhanced by metal coordination. The compounds showed moderate anticancer activity on lung A549 and cervix HeLa cancer cell lines, displaying an incubation time dependent behavior. Cellular increase of reactive oxygen species (ROS) and glutathione depletion have been measured upon incubation with the compounds. These cell killing activities were reverted when natural antioxidants were incubated with the compounds and the addition of the antioxidant agent Nacetylcysteine generated depletion of the cellular ROS levels. Therefore, a stress oxidative mechanism of action has been assumed. Moreover, the compounds showed no toxicity against Artemia salina and were not mutagenic. Both apigenin and the complex could be transported and stored by bovine serum albumin with similar binding constants and mechanisms than other VOflavonoid complexes.
format	Articulo Articulo
author	Martínez Medina, Juan José Naso, Luciana Pérez, Ana L. Rizzi, Alberto Okulik, Nora Beatriz Williams, Patricia Ana María
author_facet	Martínez Medina, Juan José Naso, Luciana Pérez, Ana L. Rizzi, Alberto Okulik, Nora Beatriz Williams, Patricia Ana María
author_sort	Martínez Medina, Juan José
title	Apigenin oxidovanadium(IV) cation interactions : Synthesis, spectral, bovine serum albumin binding, antioxidant and anticancer studies
title_short	Apigenin oxidovanadium(IV) cation interactions : Synthesis, spectral, bovine serum albumin binding, antioxidant and anticancer studies
title_full	Apigenin oxidovanadium(IV) cation interactions : Synthesis, spectral, bovine serum albumin binding, antioxidant and anticancer studies
title_fullStr	Apigenin oxidovanadium(IV) cation interactions : Synthesis, spectral, bovine serum albumin binding, antioxidant and anticancer studies
title_full_unstemmed	Apigenin oxidovanadium(IV) cation interactions : Synthesis, spectral, bovine serum albumin binding, antioxidant and anticancer studies
title_sort	apigenin oxidovanadium(iv) cation interactions : synthesis, spectral, bovine serum albumin binding, antioxidant and anticancer studies
publishDate	2017
url	http://sedici.unlp.edu.ar/handle/10915/103790 https://www.sciencedirect.com/science/article/abs/pii/S1010603017303945?via%3Dihub
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Apigenin oxidovanadium(IV) cation interactions : Synthesis, spectral, bovine serum albumin binding, antioxidant and anticancer studies

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