Computer-Aided Recognition of ABC Transporters Substrates and Its Application to the Development of New Drugs for Refractory Epilepsy
Despite the introduction of more than 15 third generation antiepileptic drugs to the market from 1990 to the moment, about one third of the epileptic patients still suffer from refractory to intractable epilepsy. Several hypotheses seek to explain the failure of drug treatments to control epilepsy s...
Guardado en:
| Autores principales: | , , , , , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/103425 |
| Aporte de: |
| id |
I19-R120-10915-103425 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia Química ABC transporters ABCB1 ABCG2 Antiepileptic drugs Breast cancer resistance protein Drug discovery P-glycoprotein Refractory epilepsy Transporter hypothesis |
| spellingShingle |
Farmacia Química ABC transporters ABCB1 ABCG2 Antiepileptic drugs Breast cancer resistance protein Drug discovery P-glycoprotein Refractory epilepsy Transporter hypothesis Couyoupetrou, Manuel Gantner, Melisa Edith Di Ianni, Mauricio Emiliano Palestro, Pablo Hernán Enrique, Andrea Verónica Gavernet, Luciana Ruiz, María Esperanza Pesce, Guido Bruno Blanch, Luis Enrique Talevi, Alan Computer-Aided Recognition of ABC Transporters Substrates and Its Application to the Development of New Drugs for Refractory Epilepsy |
| topic_facet |
Farmacia Química ABC transporters ABCB1 ABCG2 Antiepileptic drugs Breast cancer resistance protein Drug discovery P-glycoprotein Refractory epilepsy Transporter hypothesis |
| description |
Despite the introduction of more than 15 third generation antiepileptic drugs to the market from 1990 to the moment, about one third of the epileptic patients still suffer from refractory to intractable epilepsy. Several hypotheses seek to explain the failure of drug treatments to control epilepsy symptoms in such patients. The most studied one proposes that drug resistance might be related with regional overactivity of efflux transporters from the ATP-Binding Cassette (ABC) superfamily at the blood-brain barrier and/or the epileptic foci in the brain. Different strategies have been conceived to address the transporter hypothesis, among them inhibiting or down-regulating the efflux transporters or bypassing them through a diversity of artifices. Here, we review scientific evidence supporting the transporter hypothesis along with its limitations, as well as computer-assisted early recognition of ABC transporter substrates as an interesting strategy to develop novel antiepileptic drugs capable of treating refractory epilepsy linked to ABC transporters overactivity. |
| format |
Articulo Articulo |
| author |
Couyoupetrou, Manuel Gantner, Melisa Edith Di Ianni, Mauricio Emiliano Palestro, Pablo Hernán Enrique, Andrea Verónica Gavernet, Luciana Ruiz, María Esperanza Pesce, Guido Bruno Blanch, Luis Enrique Talevi, Alan |
| author_facet |
Couyoupetrou, Manuel Gantner, Melisa Edith Di Ianni, Mauricio Emiliano Palestro, Pablo Hernán Enrique, Andrea Verónica Gavernet, Luciana Ruiz, María Esperanza Pesce, Guido Bruno Blanch, Luis Enrique Talevi, Alan |
| author_sort |
Couyoupetrou, Manuel |
| title |
Computer-Aided Recognition of ABC Transporters Substrates and Its Application to the Development of New Drugs for Refractory Epilepsy |
| title_short |
Computer-Aided Recognition of ABC Transporters Substrates and Its Application to the Development of New Drugs for Refractory Epilepsy |
| title_full |
Computer-Aided Recognition of ABC Transporters Substrates and Its Application to the Development of New Drugs for Refractory Epilepsy |
| title_fullStr |
Computer-Aided Recognition of ABC Transporters Substrates and Its Application to the Development of New Drugs for Refractory Epilepsy |
| title_full_unstemmed |
Computer-Aided Recognition of ABC Transporters Substrates and Its Application to the Development of New Drugs for Refractory Epilepsy |
| title_sort |
computer-aided recognition of abc transporters substrates and its application to the development of new drugs for refractory epilepsy |
| publishDate |
2017 |
| url |
http://sedici.unlp.edu.ar/handle/10915/103425 |
| work_keys_str_mv |
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Repositorios |
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1764820441936953348 |