A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents

A sulfonamide 1-tosyl-1-H-benzo(d)imidazol-2-amine (TBZA) and three new complexes of Co(II), Cu(II), and Zn(II) have been synthesized. The compounds have been characterized by elemental analyses, FTIR, <sup>1</sup>H, and <sup>13</sup>C-NMR spectroscopy. The structure of the T...

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Detalles Bibliográficos
Autores principales:	Díaz, Jorge R. A., Fernández Baldo, Martín Alejandro, Echeverría, Gustavo Alberto, Baldoni, Héctor Armando, Vullo, Daniela, Soria, Delia Beatriz, Supuran, Claudiu T., Camí, Gerardo Enrique
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2016
Materias:	Ciencias Exactas Física Química antifungal carbonic anhydrase metal complex sulfonamide thermal stability
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/103239 https://www.tandfonline.com/doi/full/10.1080/14756366.2016.1187143
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-103239
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Exactas Física Química antifungal carbonic anhydrase metal complex sulfonamide thermal stability
spellingShingle	Ciencias Exactas Física Química antifungal carbonic anhydrase metal complex sulfonamide thermal stability Díaz, Jorge R. A. Fernández Baldo, Martín Alejandro Echeverría, Gustavo Alberto Baldoni, Héctor Armando Vullo, Daniela Soria, Delia Beatriz Supuran, Claudiu T. Camí, Gerardo Enrique A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents
topic_facet	Ciencias Exactas Física Química antifungal carbonic anhydrase metal complex sulfonamide thermal stability
description	A sulfonamide 1-tosyl-1-H-benzo(d)imidazol-2-amine (TBZA) and three new complexes of Co(II), Cu(II), and Zn(II) have been synthesized. The compounds have been characterized by elemental analyses, FTIR, <sup>1</sup>H, and <sup>13</sup>C-NMR spectroscopy. The structure of the TBZA, and its Co(II) and Cu(II) complexes, was determined by X-ray diffraction methods. TBZA and its Co(II) complex crystallize in the triclinic P-1 space group, while the Cu(II) complex crystallizes in the monoclinic P2<sub>1</sub>/c space group. Antifungal activity was screened against eight pathogenic yeasts: <i>Candida albicans</i> (DMic 972576), <i>Candida krusei</i> (DMic 951705), <i>Candida glabrata</i> (DMic 982882), <i>Candida tropicalis</i> (DMic 982884), <i>Candida dubliniensis</i> (DMic 93695), <i>Candida guilliermondii</i> (DMic 021150), <i>Cryptococcus neoformans</i> (ATCC 24067), and <i>Cryptococcus gattii</i> (ATCC MYA-4561). Results on the inhibition of various human (h) CAs, hCA I, II, IV, VII, IX, and XII, and pathogenic beta and gamma CAs are also reported.
format	Articulo Articulo
author	Díaz, Jorge R. A. Fernández Baldo, Martín Alejandro Echeverría, Gustavo Alberto Baldoni, Héctor Armando Vullo, Daniela Soria, Delia Beatriz Supuran, Claudiu T. Camí, Gerardo Enrique
author_facet	Díaz, Jorge R. A. Fernández Baldo, Martín Alejandro Echeverría, Gustavo Alberto Baldoni, Héctor Armando Vullo, Daniela Soria, Delia Beatriz Supuran, Claudiu T. Camí, Gerardo Enrique
author_sort	Díaz, Jorge R. A.
title	A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents
title_short	A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents
title_full	A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents
title_fullStr	A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents
title_full_unstemmed	A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents
title_sort	substituted sulfonamide and its co (ii), cu (ii), and zn (ii) complexes as potential antifungal agents
publishDate	2016
url	http://sedici.unlp.edu.ar/handle/10915/103239 https://www.tandfonline.com/doi/full/10.1080/14756366.2016.1187143
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A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents

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