Withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism

The absence of phytoestrogens in the diet during pregnancy has been reported to result in obesity later in adulthood. We investigated whether phytoestrogen withdrawal in adult life could alter the hypothalamic signals that regulate food intake and affect body weight and glucose homeostasis. Male Wi...

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Detalles Bibliográficos
Autores principales: Andreoli, María Florencia, Stoker, Cora, Rossetti, María Florencia, Alzamendi, Ana, Castrogiovanni, Daniel Cayetano, Luque, Enrique Hugo, Ramos, Jorge Guillermo
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2015
Materias:
Ciencias Médicas
Ciencias Exactas
Phytoestrogens
Obesity
Hypothalamus
Glucose metabolism
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/103118
https://www.sciencedirect.com/science/article/abs/pii/S0303720714003955
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-103118
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Ciencias Exactas
Phytoestrogens
Obesity
Hypothalamus
Glucose metabolism
spellingShingle Ciencias Médicas
Ciencias Exactas
Phytoestrogens
Obesity
Hypothalamus
Glucose metabolism
Andreoli, María Florencia
Stoker, Cora
Rossetti, María Florencia
Alzamendi, Ana
Castrogiovanni, Daniel Cayetano
Luque, Enrique Hugo
Ramos, Jorge Guillermo
Withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism
topic_facet Ciencias Médicas
Ciencias Exactas
Phytoestrogens
Obesity
Hypothalamus
Glucose metabolism
description The absence of phytoestrogens in the diet during pregnancy has been reported to result in obesity later in adulthood. We investigated whether phytoestrogen withdrawal in adult life could alter the hypothalamic signals that regulate food intake and affect body weight and glucose homeostasis. Male Wistar rats fed from conception to adulthood with a high phytoestrogen diet were submitted to phytoestrogen withdrawal by feeding a low phytoestrogen diet, or a high phytoestrogen–high fat diet. Withdrawal of dietary phytoestrogens increased body weight, adiposity and energy intake through an orexigenic hypothalamic response characterized by upregulation of AGRP and downregulation of POMC. This was associated with elevated leptin and T4, reduced TSH, testosterone and estradiol, and diminished hypothalamic ERα expression, concomitant with alterations in glucose tolerance. Removing dietary phytoestrogens caused manifestations of obesity and diabetes that were more pronounced than those induced by the high phytoestrogen–high fat diet intake.
format Articulo
Preprint
author Andreoli, María Florencia
Stoker, Cora
Rossetti, María Florencia
Alzamendi, Ana
Castrogiovanni, Daniel Cayetano
Luque, Enrique Hugo
Ramos, Jorge Guillermo
author_facet Andreoli, María Florencia
Stoker, Cora
Rossetti, María Florencia
Alzamendi, Ana
Castrogiovanni, Daniel Cayetano
Luque, Enrique Hugo
Ramos, Jorge Guillermo
author_sort Andreoli, María Florencia
title Withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism
title_short Withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism
title_full Withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism
title_fullStr Withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism
title_full_unstemmed Withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism
title_sort withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/103118
https://www.sciencedirect.com/science/article/abs/pii/S0303720714003955
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