Regulation of Intracellular pH is Altered in Cardiac Myocytes of Ovariectomized Rats

Background: It is well known that after menopause women are exposed to a greater cardiovascular risk, but the intracellular modifications are not properly described. The sodium/proton exchanger (NHE) and the sodium/bicarbonate cotransporter (NBC) regulate the intracellular pH and, indirectly, the in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ibañez, Alejandro Martín, Espejo, María Sofía, Zavala, Maite Raquel, Villa Abrille, María Celeste, Lofeudo, Juan Manuel, Aiello, Ernesto Alejandro, De Giusti, Verónica Celeste
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2019
Materias:	Ciencias Médicas Alcalinizing transporters Cardiac myocyte Cardiac remodeling Cardiovascular pathophysiology
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/102984
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-102984
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Médicas Alcalinizing transporters Cardiac myocyte Cardiac remodeling Cardiovascular pathophysiology
spellingShingle	Ciencias Médicas Alcalinizing transporters Cardiac myocyte Cardiac remodeling Cardiovascular pathophysiology Ibañez, Alejandro Martín Espejo, María Sofía Zavala, Maite Raquel Villa Abrille, María Celeste Lofeudo, Juan Manuel Aiello, Ernesto Alejandro De Giusti, Verónica Celeste Regulation of Intracellular pH is Altered in Cardiac Myocytes of Ovariectomized Rats
topic_facet	Ciencias Médicas Alcalinizing transporters Cardiac myocyte Cardiac remodeling Cardiovascular pathophysiology
description	Background: It is well known that after menopause women are exposed to a greater cardiovascular risk, but the intracellular modifications are not properly described. The sodium/proton exchanger (NHE) and the sodium/bicarbonate cotransporter (NBC) regulate the intracellular pH and, indirectly, the intracellular sodium concentration ([Na+]). There are 2 isoforms of NBC in the heart: the electrogenic (1Na+/2HCO 3 ; NBCe1) and the electroneutral (1Na+/1HCO 3 ; NBCn1). Because NHE and NBCn1 hyperactivity as well as the NBCe1 decreased activity have been associated with several cardiovascular pathologies, the aim of this study was to investigate the potential alterations of the alkalinizing transporters during the postmenopausal period. Methods and Results: Three-month ovariectomized rats (OVX) were used. The NHE activity and protein expression are significantly increased in OVX. The NBCe1 activity is diminished, and the NBCn1 activity becomes predominant in OVX rats. p-Akt levels showed a significant diminution in OVX. Finally, NHE activity in platelets from OVX rats is also higher in comparison to sham rats, resulting in a potential biomarker of cardiovascular diseases. Conclusions: Our results demonstrated for the first time that in the cardiac ventricular myocytes of OVX rats NHE and NBC isoforms are altered, probably because of the decreased level of p-Akt, compromising the ionic intracellular homeostasis. (J Am Heart Assoc. 2019;8:e011066. DOI: 10.1161/JAHA.118.011066.)
format	Articulo Articulo
author	Ibañez, Alejandro Martín Espejo, María Sofía Zavala, Maite Raquel Villa Abrille, María Celeste Lofeudo, Juan Manuel Aiello, Ernesto Alejandro De Giusti, Verónica Celeste
author_facet	Ibañez, Alejandro Martín Espejo, María Sofía Zavala, Maite Raquel Villa Abrille, María Celeste Lofeudo, Juan Manuel Aiello, Ernesto Alejandro De Giusti, Verónica Celeste
author_sort	Ibañez, Alejandro Martín
title	Regulation of Intracellular pH is Altered in Cardiac Myocytes of Ovariectomized Rats
title_short	Regulation of Intracellular pH is Altered in Cardiac Myocytes of Ovariectomized Rats
title_full	Regulation of Intracellular pH is Altered in Cardiac Myocytes of Ovariectomized Rats
title_fullStr	Regulation of Intracellular pH is Altered in Cardiac Myocytes of Ovariectomized Rats
title_full_unstemmed	Regulation of Intracellular pH is Altered in Cardiac Myocytes of Ovariectomized Rats
title_sort	regulation of intracellular ph is altered in cardiac myocytes of ovariectomized rats
publishDate	2019
url	http://sedici.unlp.edu.ar/handle/10915/102984
work_keys_str_mv	AT ibanezalejandromartin regulationofintracellularphisalteredincardiacmyocytesofovariectomizedrats AT espejomariasofia regulationofintracellularphisalteredincardiacmyocytesofovariectomizedrats AT zavalamaiteraquel regulationofintracellularphisalteredincardiacmyocytesofovariectomizedrats AT villaabrillemariaceleste regulationofintracellularphisalteredincardiacmyocytesofovariectomizedrats AT lofeudojuanmanuel regulationofintracellularphisalteredincardiacmyocytesofovariectomizedrats AT aielloernestoalejandro regulationofintracellularphisalteredincardiacmyocytesofovariectomizedrats AT degiustiveronicaceleste regulationofintracellularphisalteredincardiacmyocytesofovariectomizedrats
bdutipo_str	Repositorios
_version_	1764820440924028932

Regulation of Intracellular pH is Altered in Cardiac Myocytes of Ovariectomized Rats

Ejemplares similares