How Can Network-Pharmacology Contribute to Antiepileptic Drug Development?

Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant <i>magic bullet</i> paradigm which proposed the search of exquisitely selective drugs. What is more, drug targets are oft...

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Detalles Bibliográficos
Autores principales: Di Ianni, Mauricio Emiliano, Talevi, Alan
Formato: Articulo
Lenguaje:Español
Publicado: 2014
Materias:
Ciencias Exactas
Química
Biología
Drug-protein networks
Network analysis
Epilepsy
Drug repositioning
Drug repurposing
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/102558
https://ri.conicet.gov.ar/11336/31186
https://www.smartscitech.com/index.php/MCE/article/view/922
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-102558
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Español
topic Ciencias Exactas
Química
Biología
Drug-protein networks
Network analysis
Epilepsy
Drug repositioning
Drug repurposing
spellingShingle Ciencias Exactas
Química
Biología
Drug-protein networks
Network analysis
Epilepsy
Drug repositioning
Drug repurposing
Di Ianni, Mauricio Emiliano
Talevi, Alan
How Can Network-Pharmacology Contribute to Antiepileptic Drug Development?
topic_facet Ciencias Exactas
Química
Biología
Drug-protein networks
Network analysis
Epilepsy
Drug repositioning
Drug repurposing
description Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant <i>magic bullet</i> paradigm which proposed the search of exquisitely selective drugs. What is more, drug targets are often involved in multiple diseases and frequently present co-expression patterns. Therefore, useful therapeutic information can be drawn from network representations of drug targets. Here, we discuss potential applications of drug-target networks in the field of antiepileptic drug development.
format Articulo
Articulo
author Di Ianni, Mauricio Emiliano
Talevi, Alan
author_facet Di Ianni, Mauricio Emiliano
Talevi, Alan
author_sort Di Ianni, Mauricio Emiliano
title How Can Network-Pharmacology Contribute to Antiepileptic Drug Development?
title_short How Can Network-Pharmacology Contribute to Antiepileptic Drug Development?
title_full How Can Network-Pharmacology Contribute to Antiepileptic Drug Development?
title_fullStr How Can Network-Pharmacology Contribute to Antiepileptic Drug Development?
title_full_unstemmed How Can Network-Pharmacology Contribute to Antiepileptic Drug Development?
title_sort how can network-pharmacology contribute to antiepileptic drug development?
publishDate 2014
url http://sedici.unlp.edu.ar/handle/10915/102558
https://ri.conicet.gov.ar/11336/31186
https://www.smartscitech.com/index.php/MCE/article/view/922
work_keys_str_mv AT diiannimauricioemiliano howcannetworkpharmacologycontributetoantiepilepticdrugdevelopment
AT talevialan howcannetworkpharmacologycontributetoantiepilepticdrugdevelopment
bdutipo_str Repositorios
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