Genotoxicity and Cytotoxicity Exerted by Pesticides in Different Biotic Matrices-An Overview of More Than a Decade of Experimental Evaluation

Agrochemicals represent one of the most important sources of environmental pollution. Although attempts to reduce agrochemical use through organic agricultural practices and the use of other technologies to control pests continue, the problem is still unsolved. Recent technological advances in molec...

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Detalles Bibliográficos
Autores principales:	Larramendy, Marcelo Luis, Nikoloff, Noelia, Ruiz de Arcaute, Celeste, Soloneski, Sonia María Elsa
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2014
Materias:	Ciencias Naturales Agrochemicals Pesticides Commercial formulations Técnicas In Vitro In vivo Biomarkers
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/102425 https://ri.conicet.gov.ar/11336/32508 https://www.omicsonline.org/open-access/genotoxicity-and-cytotoxicity-exerted-by-pesticides-in-different-biotic-matricesan-overview-of-more-than-a-decade-of-experimental-evaluation-2161-0525.1000225.php?aid=27549
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-102425
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Naturales Agrochemicals Pesticides Commercial formulations Técnicas In Vitro In vivo Biomarkers
spellingShingle	Ciencias Naturales Agrochemicals Pesticides Commercial formulations Técnicas In Vitro In vivo Biomarkers Larramendy, Marcelo Luis Nikoloff, Noelia Ruiz de Arcaute, Celeste Soloneski, Sonia María Elsa Genotoxicity and Cytotoxicity Exerted by Pesticides in Different Biotic Matrices-An Overview of More Than a Decade of Experimental Evaluation
topic_facet	Ciencias Naturales Agrochemicals Pesticides Commercial formulations Técnicas In Vitro In vivo Biomarkers
description	Agrochemicals represent one of the most important sources of environmental pollution. Although attempts to reduce agrochemical use through organic agricultural practices and the use of other technologies to control pests continue, the problem is still unsolved. Recent technological advances in molecular biology and analytical science have allowed the development of rapid, robust, and sensitive diagnostic tests (biomarkers) that can be used to monitor exposure to, and the effects of pollution. One of the major goals of our research laboratory is to evaluate comparatively the genotoxic and cytotoxic effects exerted by several pure agrochemicals and their technical formulations commonly used in Argentina on vertebrate cells <i>in vitro</i> and <i>in vivo</i> employing several end-points for geno and cytotoxicity. Among them are listed the herbicides dicamba and flurochloridone, the fungicide zineb, the insecticides pirimicarb and imidacloprid. Overall, the results clearly demonstrated that the damage induced by the commercial formulations is in general greater than that produced by the pure pesticides, suggesting the presence of deleterious components in the excipients with either a putative intrinsic toxic effect Larramendy et al. 4 or with the capacity of exacerbating 52 the toxicity of the pure agrochemicals, or both. Accordingly, the results highlight that: 1) A complete knowledge of the toxic effect/s of the active ingredient is not enough in biomonitoring studies; 2) Pesticide/s toxic effect/s should be evaluated assaying to the commercial formulation available in market; 3) The deleterious effect/s of the excipient/s present within the commercial formulation should not be either discarded nor underestimated, and 4) A single bioassay is not enough to characterize the toxicity of a agrochemical under study.
format	Articulo Articulo
author	Larramendy, Marcelo Luis Nikoloff, Noelia Ruiz de Arcaute, Celeste Soloneski, Sonia María Elsa
author_facet	Larramendy, Marcelo Luis Nikoloff, Noelia Ruiz de Arcaute, Celeste Soloneski, Sonia María Elsa
author_sort	Larramendy, Marcelo Luis
title	Genotoxicity and Cytotoxicity Exerted by Pesticides in Different Biotic Matrices-An Overview of More Than a Decade of Experimental Evaluation
title_short	Genotoxicity and Cytotoxicity Exerted by Pesticides in Different Biotic Matrices-An Overview of More Than a Decade of Experimental Evaluation
title_full	Genotoxicity and Cytotoxicity Exerted by Pesticides in Different Biotic Matrices-An Overview of More Than a Decade of Experimental Evaluation
title_fullStr	Genotoxicity and Cytotoxicity Exerted by Pesticides in Different Biotic Matrices-An Overview of More Than a Decade of Experimental Evaluation
title_full_unstemmed	Genotoxicity and Cytotoxicity Exerted by Pesticides in Different Biotic Matrices-An Overview of More Than a Decade of Experimental Evaluation
title_sort	genotoxicity and cytotoxicity exerted by pesticides in different biotic matrices-an overview of more than a decade of experimental evaluation
publishDate	2014
url	http://sedici.unlp.edu.ar/handle/10915/102425 https://ri.conicet.gov.ar/11336/32508 https://www.omicsonline.org/open-access/genotoxicity-and-cytotoxicity-exerted-by-pesticides-in-different-biotic-matricesan-overview-of-more-than-a-decade-of-experimental-evaluation-2161-0525.1000225.php?aid=27549
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Genotoxicity and Cytotoxicity Exerted by Pesticides in Different Biotic Matrices-An Overview of More Than a Decade of Experimental Evaluation

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