Joint fitting reveals hidden interactions in tumor growth

Tumor growth is often the result of the simultaneous development of two or more cancer cell populations. Crucial to the system evolution are the interactions between these populations. To obtain information about these interactions we apply the recently developed vector universality (VUN) formalism...

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Autores principales: Barberis, Lucas Miguel, Pasquale, Miguel Ángel, Condat, Carlos A.
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2014
Materias:
Ciencias Exactas
Cancer populations
Universalities
Spheroids
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/102181
https://ri.conicet.gov.ar/11336/5461
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-102181
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Cancer populations
Universalities
Spheroids
spellingShingle Ciencias Exactas
Cancer populations
Universalities
Spheroids
Barberis, Lucas Miguel
Pasquale, Miguel Ángel
Condat, Carlos A.
Joint fitting reveals hidden interactions in tumor growth
topic_facet Ciencias Exactas
Cancer populations
Universalities
Spheroids
description Tumor growth is often the result of the simultaneous development of two or more cancer cell populations. Crucial to the system evolution are the interactions between these populations. To obtain information about these interactions we apply the recently developed vector universality (VUN) formalism to various instances of competition between tumor populations. The formalism allows us (a) to quantify the growth mechanisms of a HeLa cell colony, describing the phenotype switching responsible for its fast expansion, (b) to reliably reconstruct the evolution of the necrotic and viable fractions in both in vitro and in vivo tumors using data for the time dependences of the total masses alone, and (c) to show how the shedding of cells leading to sub-spheroid formation is beneficial to both the spheroid and sub-spheroid populations, suggesting that shedding is a strong positive influence on cancer dissemination.
format Articulo
Preprint
author Barberis, Lucas Miguel
Pasquale, Miguel Ángel
Condat, Carlos A.
author_facet Barberis, Lucas Miguel
Pasquale, Miguel Ángel
Condat, Carlos A.
author_sort Barberis, Lucas Miguel
title Joint fitting reveals hidden interactions in tumor growth
title_short Joint fitting reveals hidden interactions in tumor growth
title_full Joint fitting reveals hidden interactions in tumor growth
title_fullStr Joint fitting reveals hidden interactions in tumor growth
title_full_unstemmed Joint fitting reveals hidden interactions in tumor growth
title_sort joint fitting reveals hidden interactions in tumor growth
publishDate 2014
url http://sedici.unlp.edu.ar/handle/10915/102181
https://ri.conicet.gov.ar/11336/5461
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AT pasqualemiguelangel jointfittingrevealshiddeninteractionsintumorgrowth
AT condatcarlosa jointfittingrevealshiddeninteractionsintumorgrowth
bdutipo_str Repositorios
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