Small bowel transplantation in rats, a multicenter experience summarizing the pitfalls to be overcome
Small Bowel transplantation in rats is a highly complex microsurgical procedure because several technical complications may lead to recipient mortality and transplant failure. Our aim was to report the most common complications associated with orthotopic and heterotopic intestinal transplantation in...
| Autores principales: | , , , , , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/101282 https://ri.conicet.gov.ar/11336/48434 http://www.oatext.com/Small-bowel-transplantation-in-rats,-A-multicenter-experience-summarizing-the-pitfalls-to-be-overcome.php |
| Aporte de: |
| id |
I19-R120-10915-101282 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Medicina Ciencias Exactas Intestinal transplantation Surgical compliations Rats Microsurgery |
| spellingShingle |
Medicina Ciencias Exactas Intestinal transplantation Surgical compliations Rats Microsurgery Stringa, Pablo Luis Andrés Moreno, Ane M. Lausada, Natalia Raquel Pastor Oliver, Cristina Abate Zárate, Juan Cruz Vecchio Dezillio, Leandro Emmanuel Rumbo, Martín Navarro Zorraquino, Marta Hernández Oliveros, Francisco Gondolesi, Gabriel Eduardo Small bowel transplantation in rats, a multicenter experience summarizing the pitfalls to be overcome |
| topic_facet |
Medicina Ciencias Exactas Intestinal transplantation Surgical compliations Rats Microsurgery |
| description |
Small Bowel transplantation in rats is a highly complex microsurgical procedure because several technical complications may lead to recipient mortality and transplant failure. Our aim was to report the most common complications associated with orthotopic and heterotopic intestinal transplantation in rats in order to identify the “pitfalls” of the procedure and prevent them. A retrospective multicenter study was performed. All participant centers have established rodent transplant procedures and trained surgeons. Two hundred ninety-three complications from 264 unsuccessful intestinal transplants were reported, representing an overall failure rate of 15% of the procedures performed. Recipient complications were most frequent than donor (257 vs. 36 p<0.0001). Excessive surgical time (11/36); severe hemorrhage (12/36) and inappropriate infusion of the preservation solution in the intestinal graft (11/36) were the most common donor complications. Arterial anastomosis bleeding (50/257), venous anastomosis bleeding (35/257) and portal vein stenosis (26/257) were the most common intraoperative complications in the recipient. To maximize success rate, surgeons should optimize time and avoid bleeding during graft dissection in the donor surgery. After performing a bloodless vascular anastomosis an adequate post-operative management of the animal is mandatory to guarantee survival. |
| format |
Articulo Articulo |
| author |
Stringa, Pablo Luis Andrés Moreno, Ane M. Lausada, Natalia Raquel Pastor Oliver, Cristina Abate Zárate, Juan Cruz Vecchio Dezillio, Leandro Emmanuel Rumbo, Martín Navarro Zorraquino, Marta Hernández Oliveros, Francisco Gondolesi, Gabriel Eduardo |
| author_facet |
Stringa, Pablo Luis Andrés Moreno, Ane M. Lausada, Natalia Raquel Pastor Oliver, Cristina Abate Zárate, Juan Cruz Vecchio Dezillio, Leandro Emmanuel Rumbo, Martín Navarro Zorraquino, Marta Hernández Oliveros, Francisco Gondolesi, Gabriel Eduardo |
| author_sort |
Stringa, Pablo Luis |
| title |
Small bowel transplantation in rats, a multicenter experience summarizing the pitfalls to be overcome |
| title_short |
Small bowel transplantation in rats, a multicenter experience summarizing the pitfalls to be overcome |
| title_full |
Small bowel transplantation in rats, a multicenter experience summarizing the pitfalls to be overcome |
| title_fullStr |
Small bowel transplantation in rats, a multicenter experience summarizing the pitfalls to be overcome |
| title_full_unstemmed |
Small bowel transplantation in rats, a multicenter experience summarizing the pitfalls to be overcome |
| title_sort |
small bowel transplantation in rats, a multicenter experience summarizing the pitfalls to be overcome |
| publishDate |
2016 |
| url |
http://sedici.unlp.edu.ar/handle/10915/101282 https://ri.conicet.gov.ar/11336/48434 http://www.oatext.com/Small-bowel-transplantation-in-rats,-A-multicenter-experience-summarizing-the-pitfalls-to-be-overcome.php |
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