Reactive oxygen species-mediated degradation of antidiabetic compounds: Cytotoxic implications of their photodegradation products

Reactive oxygen species (ROS) have been described in their double physiological function, helping in the maintenance of health as well as contributing to oxidative stress. Diabetes mellitus is a chronical disease nearly related to oxidative stress, whose treatment (in type II variant) consists in th...

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Autores principales:	Challier, Cecilia, Laurella, Sergio Luis, Allegretti, Patricia Ercilia, Sabini, María Carola, Sabini, Liliana Inés, García, Norman Andino, Biasutti, María Alicia, Criado, Susana Noemí
Formato:	Articulo Preprint
Lenguaje:	Inglés
Publicado:	2018
Materias:	Química Reactive oxygen species Antidiabetic compounds Diabetes mellitus Cytotoxicity
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/100880 https://ri.conicet.gov.ar/11336/91972
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-100880
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Química Reactive oxygen species Antidiabetic compounds Diabetes mellitus Cytotoxicity
spellingShingle	Química Reactive oxygen species Antidiabetic compounds Diabetes mellitus Cytotoxicity Challier, Cecilia Laurella, Sergio Luis Allegretti, Patricia Ercilia Sabini, María Carola Sabini, Liliana Inés García, Norman Andino Biasutti, María Alicia Criado, Susana Noemí Reactive oxygen species-mediated degradation of antidiabetic compounds: Cytotoxic implications of their photodegradation products
topic_facet	Química Reactive oxygen species Antidiabetic compounds Diabetes mellitus Cytotoxicity
description	Reactive oxygen species (ROS) have been described in their double physiological function, helping in the maintenance of health as well as contributing to oxidative stress. Diabetes mellitus is a chronical disease nearly related to oxidative stress, whose treatment (in type II variant) consists in the administration of antidiabetic compounds (Andb) such as Gliclazide (Gli) and Glipizide (Glip). In this context, as Andb may be exposed to high ROS concentrations in diabetic patients, we have studied the potential ROS-mediated degradation of Gli and Glip through photosensitized processes, in the presence of Riboflavin (Rf) vitamin. We found that singlet oxygen (O 2 ( 1 ∆ g )) participated in the Rf-sensitized photodegradation of both Andb, and also superoxide radical anion in the case of Gli. Two principal products derived from O 2 ( 1 ∆ g )-mediated degradation of Gli were identified and their chemical structures characterized, through HPLC mass spectrometry. O 2 ( 1 ∆ g )-mediated degradation products and their toxicity was assayed on Vero cell line. These studies demonstrated that neither Gli nor its photoproducts caused cytotoxic effect under the experimental conditions assayed. Our results show strong evidences of ROS-mediated Andb degradation, which may involve the reduction or loss of their therapeutic action, as well as potential cytotoxicity derived from their oxidation products.
format	Articulo Preprint
author	Challier, Cecilia Laurella, Sergio Luis Allegretti, Patricia Ercilia Sabini, María Carola Sabini, Liliana Inés García, Norman Andino Biasutti, María Alicia Criado, Susana Noemí
author_facet	Challier, Cecilia Laurella, Sergio Luis Allegretti, Patricia Ercilia Sabini, María Carola Sabini, Liliana Inés García, Norman Andino Biasutti, María Alicia Criado, Susana Noemí
author_sort	Challier, Cecilia
title	Reactive oxygen species-mediated degradation of antidiabetic compounds: Cytotoxic implications of their photodegradation products
title_short	Reactive oxygen species-mediated degradation of antidiabetic compounds: Cytotoxic implications of their photodegradation products
title_full	Reactive oxygen species-mediated degradation of antidiabetic compounds: Cytotoxic implications of their photodegradation products
title_fullStr	Reactive oxygen species-mediated degradation of antidiabetic compounds: Cytotoxic implications of their photodegradation products
title_full_unstemmed	Reactive oxygen species-mediated degradation of antidiabetic compounds: Cytotoxic implications of their photodegradation products
title_sort	reactive oxygen species-mediated degradation of antidiabetic compounds: cytotoxic implications of their photodegradation products
publishDate	2018
url	http://sedici.unlp.edu.ar/handle/10915/100880 https://ri.conicet.gov.ar/11336/91972
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bdutipo_str	Repositorios
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Reactive oxygen species-mediated degradation of antidiabetic compounds: Cytotoxic implications of their photodegradation products

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