Dietary fats significantly influence the survival of penumbral neurons in a permanent isquemic stroke rat model by modifying lipid mediators, inflammatory biomarkers, nos production, and redox-dependent apoptotic signals
Objective: Brain stroke is the third most important cause of death in developed countries. We studied the effect of different dietary lipids on the outcome of a permanent ischemic stroke rat model. Methods: Wistar rats were fed diets containing 7% commercial oils (S, soybean; O, olive; C, coconut;...
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| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Articulo Preprint |
| Lenguaje: | Inglés |
| Publicado: |
2015
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/100028 https://ri.conicet.gov.ar/11336/12434 |
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I19-R120-10915-100028 |
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dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Bioquímica Dietary lipids Ischemic stroke Neuronal death Lipid mediators Oxidative stress Inflammation |
| spellingShingle |
Bioquímica Dietary lipids Ischemic stroke Neuronal death Lipid mediators Oxidative stress Inflammation Lausada, Natalia Raquel Arnal, Nathalie Astiz, Mariana Marin, Maria Cristina Lofeudo, Juan Manuel Stringa, Pablo Tacconi de Alaniz, María Josefa Tacconi de Gómez Dumm, Irma Nelva Hurtado, Graciela Elisa Cristalli de Piñero, Norma Pallanza, Maria Cristina Illara, Maria Eva Bozzarello, Enrique Gustavo Cristalli, Diana Marra, Carlos Alberto Dietary fats significantly influence the survival of penumbral neurons in a permanent isquemic stroke rat model by modifying lipid mediators, inflammatory biomarkers, nos production, and redox-dependent apoptotic signals |
| topic_facet |
Bioquímica Dietary lipids Ischemic stroke Neuronal death Lipid mediators Oxidative stress Inflammation |
| description |
Objective: Brain stroke is the third most important cause of death in developed countries. We studied the effect of different dietary lipids on the outcome of a permanent ischemic stroke rat model.
Methods: Wistar rats were fed diets containing 7% commercial oils (S, soybean; O, olive; C, coconut; G, grape seed) for 35 d. Stroke was induced by permanent middle cerebral artery occlusion. Coronal slices from ischemic brains and sham-operated animals were supravitally stained. Penumbra and core volumes were calculated by image digitalization after 24, 48, and 72 h poststroke. Homogenates and mitochondrial fractions were prepared from different zones and analyzed by redox status, inflammatory markers, ceramide, and arachidonate content, phospholipase A2, NOS, and proteases.
Results: Soybean (S) and G diets were mainly prooxidative and proinflammatory by increasing the liberation of arachidonate and its transformation into prostaglandins. O was protective in terms of redox homeostatic balance, minor increases in lipid and protein damage, conservation of reduced glutathione, protective activation of NOS in penumbra, and net ratio of anti-to proinflammatory cytokines. Apoptosis (caspase-3, milli- and microcalpains) was less activated by O than by any other diet.
Conclusion: Dietary lipids modulate NOS and PLA2 activities, ceramide production, and glutathione import into the mitochondrial matrix, finally determining the activation of the two main protease systems involved in programmed cell death. Olive oil appears to be a biological source for the isolation of protective agents that block the expansion of brain core at the expense of penumbral neurons. |
| format |
Articulo Preprint |
| author |
Lausada, Natalia Raquel Arnal, Nathalie Astiz, Mariana Marin, Maria Cristina Lofeudo, Juan Manuel Stringa, Pablo Tacconi de Alaniz, María Josefa Tacconi de Gómez Dumm, Irma Nelva Hurtado, Graciela Elisa Cristalli de Piñero, Norma Pallanza, Maria Cristina Illara, Maria Eva Bozzarello, Enrique Gustavo Cristalli, Diana Marra, Carlos Alberto |
| author_facet |
Lausada, Natalia Raquel Arnal, Nathalie Astiz, Mariana Marin, Maria Cristina Lofeudo, Juan Manuel Stringa, Pablo Tacconi de Alaniz, María Josefa Tacconi de Gómez Dumm, Irma Nelva Hurtado, Graciela Elisa Cristalli de Piñero, Norma Pallanza, Maria Cristina Illara, Maria Eva Bozzarello, Enrique Gustavo Cristalli, Diana Marra, Carlos Alberto |
| author_sort |
Lausada, Natalia Raquel |
| title |
Dietary fats significantly influence the survival of penumbral neurons in a permanent isquemic stroke rat model by modifying lipid mediators, inflammatory biomarkers, nos production, and redox-dependent apoptotic signals |
| title_short |
Dietary fats significantly influence the survival of penumbral neurons in a permanent isquemic stroke rat model by modifying lipid mediators, inflammatory biomarkers, nos production, and redox-dependent apoptotic signals |
| title_full |
Dietary fats significantly influence the survival of penumbral neurons in a permanent isquemic stroke rat model by modifying lipid mediators, inflammatory biomarkers, nos production, and redox-dependent apoptotic signals |
| title_fullStr |
Dietary fats significantly influence the survival of penumbral neurons in a permanent isquemic stroke rat model by modifying lipid mediators, inflammatory biomarkers, nos production, and redox-dependent apoptotic signals |
| title_full_unstemmed |
Dietary fats significantly influence the survival of penumbral neurons in a permanent isquemic stroke rat model by modifying lipid mediators, inflammatory biomarkers, nos production, and redox-dependent apoptotic signals |
| title_sort |
dietary fats significantly influence the survival of penumbral neurons in a permanent isquemic stroke rat model by modifying lipid mediators, inflammatory biomarkers, nos production, and redox-dependent apoptotic signals |
| publishDate |
2015 |
| url |
http://sedici.unlp.edu.ar/handle/10915/100028 https://ri.conicet.gov.ar/11336/12434 |
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