Linear Causation Schemes in Post-genomic Biology: The Subliminal and Convenient One-to-one Genotype-Phenotype Mapping Assumption
Abstract | In this essay we question the validity of basic assumptions in molecular biology and evolution on the basis of recent experimental data and through the lenses of a systems and nonlinear perspective. We focus our discussion on two well-established foundations of biology: the flow of inform...
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| Formato: | Artículo publishedVersion |
| Lenguaje: | Español |
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Centro de Investigaciones Interdisciplinarias en Ciencias y Humanidades
2015
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| Acceso en línea: | http://www.revistas.unam.mx/index.php/inter/article/view/47627 http://biblioteca.clacso.edu.ar/gsdl/cgi-bin/library.cgi?a=d&c=mx/mx-005&d=article47627oai |
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I16-R122-article47627oai |
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dspace |
| institution |
Consejo Latinoamericano de Ciencias Sociales |
| institution_str |
I-16 |
| repository_str |
R-122 |
| collection |
Red de Bibliotecas Virtuales de Ciencias Sociales (CLACSO) |
| language |
Español |
| description |
Abstract | In this essay we question the validity of basic assumptions in molecular biology and evolution on the basis of recent experimental data and through the lenses of a systems and nonlinear perspective. We focus our discussion on two well-established foundations of biology: the flow of information in molecular biology (i.e., the central dogma of molecular biology), and the “causal” linear signaling pathway paradigm.Under both paradigms the subliminal assumption of a one-to-one genotype-phenotype mapping (GPM) constitutes an underlying working hypothesis in many cases. We ask if this is empirically sustainable in post-genomic biology. We conclude that when embracing the notion of complex networks and dynamical processes governing cellular behavior — a view now empirically validated — one-to-one mapping can no longer be sustained. We hypothesize that such subliminal and sometimes explicit assumption may be upheld, to a certain degree, because it is convenient for the private appropriation and marketing of scientific discoveries. Hopefully, our discussion will help smooth the undergoing transition towards a more integrative, explanatory, quantitative and multidisciplinary systems biology. The latter will likely also yield more preventive and sustainable medical and agricultural developments, respectively, than a reductionist approach. |
| format |
Artículo publishedVersion Artículo publishedVersion |
| author |
Dávila-Velderrain, José; Instituto de Ecología-Universidad Nacional Autónoma de México. Álvarez-Buylla Roces, Elena; Centro de Ciencias de la Complejidad-Universidad Nacional Autónoma de México. |
| spellingShingle |
Dávila-Velderrain, José; Instituto de Ecología-Universidad Nacional Autónoma de México. Álvarez-Buylla Roces, Elena; Centro de Ciencias de la Complejidad-Universidad Nacional Autónoma de México. Linear Causation Schemes in Post-genomic Biology: The Subliminal and Convenient One-to-one Genotype-Phenotype Mapping Assumption |
| author_facet |
Dávila-Velderrain, José; Instituto de Ecología-Universidad Nacional Autónoma de México. Álvarez-Buylla Roces, Elena; Centro de Ciencias de la Complejidad-Universidad Nacional Autónoma de México. |
| author_sort |
Dávila-Velderrain, José; Instituto de Ecología-Universidad Nacional Autónoma de México. |
| title |
Linear Causation Schemes in Post-genomic Biology: The Subliminal and Convenient One-to-one Genotype-Phenotype Mapping Assumption |
| title_short |
Linear Causation Schemes in Post-genomic Biology: The Subliminal and Convenient One-to-one Genotype-Phenotype Mapping Assumption |
| title_full |
Linear Causation Schemes in Post-genomic Biology: The Subliminal and Convenient One-to-one Genotype-Phenotype Mapping Assumption |
| title_fullStr |
Linear Causation Schemes in Post-genomic Biology: The Subliminal and Convenient One-to-one Genotype-Phenotype Mapping Assumption |
| title_full_unstemmed |
Linear Causation Schemes in Post-genomic Biology: The Subliminal and Convenient One-to-one Genotype-Phenotype Mapping Assumption |
| title_sort |
linear causation schemes in post-genomic biology: the subliminal and convenient one-to-one genotype-phenotype mapping assumption |
| publisher |
Centro de Investigaciones Interdisciplinarias en Ciencias y Humanidades |
| publishDate |
2015 |
| url |
http://www.revistas.unam.mx/index.php/inter/article/view/47627 http://biblioteca.clacso.edu.ar/gsdl/cgi-bin/library.cgi?a=d&c=mx/mx-005&d=article47627oai |
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