Immunity in decline: How aging reshapes the immune adaptive response
The physiological aging of the immune system, known as immunosenescence, exhibits distinctive characteristics that affect both the lymphoid and myeloid compartments. These alterations are closely associated with the onset of various age-related chronic diseases, such as cancer and neurodegenerative...
Guardado en:
| Autores principales: | , , , , , , |
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional de Rosario
2025
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| Materias: | |
| Acceso en línea: | https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/134 |
| Aporte de: |
| Sumario: | The physiological aging of the immune system, known as immunosenescence, exhibits distinctive characteristics that affect both the lymphoid and myeloid compartments. These alterations are closely associated with the onset of various age-related chronic diseases, such as cancer and neurodegenerative disorders, as well as increased susceptibility to pathogens and a reduced response to vaccines. In this review, we will focus on the changes experienced by T and B lymphocytes as a consequence of immune system aging, as understanding these processes is essential for studying the pathophysiology of multiple chronic conditions and developing therapeutic strategies aimed at preventing premature immune aging. |
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