Immunity in decline: How aging reshapes the immune adaptive response
The physiological aging of the immune system, known as immunosenescence, exhibits distinctive characteristics that affect both the lymphoid and myeloid compartments. These alterations are closely associated with the onset of various age-related chronic diseases, such as cancer and neurodegenerative...
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional de Rosario
2025
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| Acceso en línea: | https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/134 |
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I15-R235-article-1342025-07-04T17:40:01Z Immunity in decline: How aging reshapes the immune adaptive response Inmunidad en declive: Cómo el envejecimiento remodela la respuesta inmune adaptativa Dinatale, Brenda Bulfoni Balbi, Camila González, Florencia Belén Pacini, María Florencia Moreno, María Ailén Lioi, Susana Pérez, Ana Rosa respuesta adaptativa inflamación crónica inmunosenescencia linfocitaria Immunosenescence Lymphocytes Chronic inflammation Adaptive response The physiological aging of the immune system, known as immunosenescence, exhibits distinctive characteristics that affect both the lymphoid and myeloid compartments. These alterations are closely associated with the onset of various age-related chronic diseases, such as cancer and neurodegenerative disorders, as well as increased susceptibility to pathogens and a reduced response to vaccines. In this review, we will focus on the changes experienced by T and B lymphocytes as a consequence of immune system aging, as understanding these processes is essential for studying the pathophysiology of multiple chronic conditions and developing therapeutic strategies aimed at preventing premature immune aging. El envejecimiento fisiológico del sistema inmune, conocido como inmunosenescencia, presenta características distintivas que afectan tanto al compartimiento linfoide como al mieloide. Estas alteraciones están estrechamente relacionadas con la aparición de diversas patologías crónicas asociadas a la edad, como cáncer y enfermedades neurodegenerativas, así como con una mayor susceptibilidad a patógenos y una respuesta disminuida a las vacunas. En esta revisión, nos centraremos en los cambios que experimentan los linfocitos T y B como consecuencia del envejecimiento del sistema inmunológico, dado que comprender estos procesos es fundamental para el estudio de la fisiopatología de múltiples afecciones crónicas y el desarrollo de estrategias terapéuticas destinadas a prevenir el envejecimiento prematuro del sistema inmune. Universidad Nacional de Rosario 2025-07-04 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/134 10.35305/fcm.v4i.134 Revista de la Facultad de Ciencias Médicas. Universidad Nacional de Rosario.; Vol. 4 (2025) 2796-7719 spa https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/134/104 Derechos de autor 2025 Revista de la Facultad de Ciencias Médicas. Universidad Nacional de Rosario. https://creativecommons.org/licenses/by-nc/4.0 |
| institution |
Universidad Nacional de Rosario |
| institution_str |
I-15 |
| repository_str |
R-235 |
| container_title_str |
FCM Científica |
| language |
Español |
| format |
Artículo revista |
| topic |
respuesta adaptativa inflamación crónica inmunosenescencia linfocitaria Immunosenescence Lymphocytes Chronic inflammation Adaptive response |
| spellingShingle |
respuesta adaptativa inflamación crónica inmunosenescencia linfocitaria Immunosenescence Lymphocytes Chronic inflammation Adaptive response Dinatale, Brenda Bulfoni Balbi, Camila González, Florencia Belén Pacini, María Florencia Moreno, María Ailén Lioi, Susana Pérez, Ana Rosa Immunity in decline: How aging reshapes the immune adaptive response |
| topic_facet |
respuesta adaptativa inflamación crónica inmunosenescencia linfocitaria Immunosenescence Lymphocytes Chronic inflammation Adaptive response |
| author |
Dinatale, Brenda Bulfoni Balbi, Camila González, Florencia Belén Pacini, María Florencia Moreno, María Ailén Lioi, Susana Pérez, Ana Rosa |
| author_facet |
Dinatale, Brenda Bulfoni Balbi, Camila González, Florencia Belén Pacini, María Florencia Moreno, María Ailén Lioi, Susana Pérez, Ana Rosa |
| author_sort |
Dinatale, Brenda |
| title |
Immunity in decline: How aging reshapes the immune adaptive response |
| title_short |
Immunity in decline: How aging reshapes the immune adaptive response |
| title_full |
Immunity in decline: How aging reshapes the immune adaptive response |
| title_fullStr |
Immunity in decline: How aging reshapes the immune adaptive response |
| title_full_unstemmed |
Immunity in decline: How aging reshapes the immune adaptive response |
| title_sort |
immunity in decline: how aging reshapes the immune adaptive response |
| description |
The physiological aging of the immune system, known as immunosenescence, exhibits distinctive characteristics that affect both the lymphoid and myeloid compartments. These alterations are closely associated with the onset of various age-related chronic diseases, such as cancer and neurodegenerative disorders, as well as increased susceptibility to pathogens and a reduced response to vaccines. In this review, we will focus on the changes experienced by T and B lymphocytes as a consequence of immune system aging, as understanding these processes is essential for studying the pathophysiology of multiple chronic conditions and developing therapeutic strategies aimed at preventing premature immune aging. |
| publisher |
Universidad Nacional de Rosario |
| publishDate |
2025 |
| url |
https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/134 |
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2025-09-04T05:06:41Z |
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2025-09-04T05:06:41Z |
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