Intestinal barrier function: Alteration and implications in inflammatory bowel diseases
The intestinal barrier plays an important role in defending against toxins, xenobiotics and potentially harmful molecules, while allowing the absorption of nutrients, electrolytes and water. These functions are carried out by specialized epithelial cells, in which selective permeability is achieved...
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| Autores principales: | , , , |
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional de Rosario
2025
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| Acceso en línea: | https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/119 |
| Aporte de: |
| Sumario: | The intestinal barrier plays an important role in defending against toxins, xenobiotics and potentially harmful molecules, while allowing the absorption of nutrients, electrolytes and water. These functions are carried out by specialized epithelial cells, in which selective permeability is achieved through two pathways: paracellular and transcellular. The first involves the entry of molecules through the space between cells, while the transcellular pathway involves the movement of molecules across cell membranes and is mediated by apical and basolateral transmembrane transporters. Deregulation of these pathways is implicated in the pathogenesis of inflammatory bowel diseases, including Crohn's disease and ulcerative colitis.
This review describes the advances in understanding the components of the intestinal barrier, their regulation, and their implications in inflammatory bowel diseases. This is highly relevant for understanding the mechanisms involved in the pathophysiology and for the development of future therapies for these conditions. |
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