Intestinal barrier function: Alteration and implications in inflammatory bowel diseases

The intestinal barrier plays an important role in defending against toxins, xenobiotics and potentially harmful molecules, while allowing the absorption of nutrients, electrolytes and water. These functions are carried out by specialized epithelial cells, in which selective permeability is achieved...

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Autores principales: Villanueva, Silvina, Ricardi, Laura Lis, Zecchinati, Felipe, Arana, Maite Rocío
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional de Rosario 2025
Materias:
Barrera Intestinal
regulación
implicancias
Enfermedades Inflamatorias Intestinales
Acceso en línea:https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/119
Aporte de:
FCM Científica de Universidad Nacional de Rosario
id I15-R235-article-119
record_format ojs
spelling I15-R235-article-1192025-07-04T17:23:58Z Intestinal barrier function: Alteration and implications in inflammatory bowel diseases Función de barrera intestinal: Alteración e implicancias en las enfermedades inflamatorias intestinales Villanueva, Silvina Ricardi, Laura Lis Zecchinati, Felipe Arana, Maite Rocío Barrera Intestinal regulación implicancias Enfermedades Inflamatorias Intestinales The intestinal barrier plays an important role in defending against toxins, xenobiotics and potentially harmful molecules, while allowing the absorption of nutrients, electrolytes and water. These functions are carried out by specialized epithelial cells, in which selective permeability is achieved through two pathways: paracellular and transcellular. The first involves the entry of molecules through the space between cells, while the transcellular pathway involves the movement of molecules across cell membranes and is mediated by apical and basolateral transmembrane transporters. Deregulation of these pathways is implicated in the pathogenesis of inflammatory bowel diseases, including Crohn's disease and ulcerative colitis. This review describes the advances in understanding the components of the intestinal barrier, their regulation, and their implications in inflammatory bowel diseases. This is highly relevant for understanding the mechanisms involved in the pathophysiology and for the development of future therapies for these conditions. La barrera intestinal cumple un rol importante en la defensa contra toxinas, xenobióticos y moléculas potencialmente dañinas, al tiempo que permite la absorción de nutrientes, electrolitos y agua. Estas funciones son llevadas a cabo por células epiteliales especializadas, en las cuales la permeabilidad selectiva se logra a través de dos vías: paracelular y transcelular. La primera comprende el ingreso de moléculas a través del espacio entre las células, mientras que la vía transcelular implica el movimiento de moléculas a través de las membranas celulares y está mediado por transportadores transmembrana apicales y basolaterales. La desregulación de estas vías está implicada en la patogénesis de las enfermedades inflamatorias intestinales, incluyendo la enfermedad de Crohn y la colitis ulcerosa. En esta revisión se describen los avances en el conocimiento de los componentes de la barrera intestinal, su regulación y su implicancia en las enfermedades inflamatorias intestinales. Esto es de gran relevancia para comprender los mecanismos involucrados en la fisiopatología y para el desarrollo de futuras terapias para estas afecciones. Universidad Nacional de Rosario 2025-07-04 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/119 10.35305/fcm.v4i.119 Revista de la Facultad de Ciencias Médicas. Universidad Nacional de Rosario.; Vol. 4 (2025) 2796-7719 spa https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/119/102 Derechos de autor 2025 Revista de la Facultad de Ciencias Médicas. Universidad Nacional de Rosario. https://creativecommons.org/licenses/by-nc/4.0
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-235
container_title_str FCM Científica
language Español
format Artículo revista
topic Barrera Intestinal
regulación
implicancias
Enfermedades Inflamatorias Intestinales
spellingShingle Barrera Intestinal
regulación
implicancias
Enfermedades Inflamatorias Intestinales
Villanueva, Silvina
Ricardi, Laura Lis
Zecchinati, Felipe
Arana, Maite Rocío
Intestinal barrier function: Alteration and implications in inflammatory bowel diseases
topic_facet Barrera Intestinal
regulación
implicancias
Enfermedades Inflamatorias Intestinales
author Villanueva, Silvina
Ricardi, Laura Lis
Zecchinati, Felipe
Arana, Maite Rocío
author_facet Villanueva, Silvina
Ricardi, Laura Lis
Zecchinati, Felipe
Arana, Maite Rocío
author_sort Villanueva, Silvina
title Intestinal barrier function: Alteration and implications in inflammatory bowel diseases
title_short Intestinal barrier function: Alteration and implications in inflammatory bowel diseases
title_full Intestinal barrier function: Alteration and implications in inflammatory bowel diseases
title_fullStr Intestinal barrier function: Alteration and implications in inflammatory bowel diseases
title_full_unstemmed Intestinal barrier function: Alteration and implications in inflammatory bowel diseases
title_sort intestinal barrier function: alteration and implications in inflammatory bowel diseases
description The intestinal barrier plays an important role in defending against toxins, xenobiotics and potentially harmful molecules, while allowing the absorption of nutrients, electrolytes and water. These functions are carried out by specialized epithelial cells, in which selective permeability is achieved through two pathways: paracellular and transcellular. The first involves the entry of molecules through the space between cells, while the transcellular pathway involves the movement of molecules across cell membranes and is mediated by apical and basolateral transmembrane transporters. Deregulation of these pathways is implicated in the pathogenesis of inflammatory bowel diseases, including Crohn's disease and ulcerative colitis. This review describes the advances in understanding the components of the intestinal barrier, their regulation, and their implications in inflammatory bowel diseases. This is highly relevant for understanding the mechanisms involved in the pathophysiology and for the development of future therapies for these conditions.
publisher Universidad Nacional de Rosario
publishDate 2025
url https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/119
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first_indexed 2025-09-04T05:06:38Z
last_indexed 2025-09-04T05:06:38Z
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