Isolated third cranial nerve ophthalmoparesis, an atypical form of presentation in non-Hodgkin's lymphoma.: Ophthalmoparesis of the third cranial nerve a rare presentation in non-Hodgkins lymphoma

We present a patient with non-Hodgkin's lymphoma with isolated ophthalmoparesis of the III cranial pair. We describe the clinical, radiological and analytical characteristics of the cerebrospinal fluid that made the diagnosis difficult, in a 55-year-old man with C virus carriage, hepatocarcinom...

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Autores principales: Rodriguez, Cintia Pamela, Firpo, Camila Ayelén, Lazarte, Yobana Delina, Capriotti, Jorge Pedro
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional de Rosario 2025
Materias:
linfoma
oftalmoparesia
tercer par craneal
Acceso en línea:https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/117
Aporte de:
FCM Científica de Universidad Nacional de Rosario
id I15-R235-article-117
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spelling I15-R235-article-1172025-07-04T18:49:45Z Isolated third cranial nerve ophthalmoparesis, an atypical form of presentation in non-Hodgkin's lymphoma.: Ophthalmoparesis of the third cranial nerve a rare presentation in non-Hodgkins lymphoma Oftalmoparesia del tercer par craneal aislada, una forma atípica de presentación en el Linfoma no Hodgkin: Oftalmoparesia del tercer par craneal una presentación rara en el Linfoma no Hodgkin Rodriguez, Cintia Pamela Firpo, Camila Ayelén Lazarte, Yobana Delina Capriotti, Jorge Pedro linfoma oftalmoparesia tercer par craneal We present a patient with non-Hodgkin's lymphoma with isolated ophthalmoparesis of the III cranial pair. We describe the clinical, radiological and analytical characteristics of the cerebrospinal fluid that made the diagnosis difficult, in a 55-year-old man with C virus carriage, hepatocarcinoma in remission and ethylism. He presented with isolated right third cranial nerve palsy, with pupillary involvement. The initial MRI showed increased thickness and enhancement of this nerve. Cerebrospinal fluid analysis showed no pathological findings. In the following months, due to clinical progression, the MRI was repeated and showed evidence of extension of the lesion. New CSF samples showed pleocytosis and hyperproteinorrachia, with negative cytology, cultures and flow cytometry. A biopsy was decided which revealed type B non-Hodgkin's lymphoma. We conducted a literature search where we found to date 12 cases of isolated paralysis of the third pair as clinical presentation of this type of lymphoma, being a rare form and to be considered in certain patients. Presentamos un paciente con Linfoma no Hodgkin con oftalmoparesia aislada del III par craneal. Describimos las características clínicas, radiológicas y analíticas del líquido cefalorraquídeo que dificultó el diagnóstico, en un hombre de 55 años con portación de virus C, hepatocarcinoma en remisión y de etilismo. Presentaba una parálisis aislada del III par craneal derecho, con afectación pupilar. La resonancia magnética inicial mostró aumento del espesor y realce de dicho nervio. El análisis del líquido cefalorraquídeo no mostró hallazgos patológicos. En los meses subsiguientes por progresión clínica se repite resonancia que evidencia extensión de la lesión. En nuevas muestras de LCR se observa pleocitosis e hiperproteinorraquía, con citología, cultivos y citometría de flujo negativas. Se decide biopsia que revela Linfoma no Hodgkin tipo B. Realizamos una búsqueda bibliográfica donde encontramos a la fecha 12 casos de parálisis aislada del III par como presentación clínica de este tipo de Linfoma, siendo una forma rara y a pensar en ciertos pacientes. Universidad Nacional de Rosario 2025-07-04 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/117 10.35305/fcm.v4i.117 Revista de la Facultad de Ciencias Médicas. Universidad Nacional de Rosario.; Vol. 4 (2025) 2796-7719 spa https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/117/111 Derechos de autor 2025 Revista de la Facultad de Ciencias Médicas. Universidad Nacional de Rosario. https://creativecommons.org/licenses/by-nc/4.0
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-235
container_title_str FCM Científica
language Español
format Artículo revista
topic linfoma
oftalmoparesia
tercer par craneal
spellingShingle linfoma
oftalmoparesia
tercer par craneal
Rodriguez, Cintia Pamela
Firpo, Camila Ayelén
Lazarte, Yobana Delina
Capriotti, Jorge Pedro
Isolated third cranial nerve ophthalmoparesis, an atypical form of presentation in non-Hodgkin's lymphoma.: Ophthalmoparesis of the third cranial nerve a rare presentation in non-Hodgkins lymphoma
topic_facet linfoma
oftalmoparesia
tercer par craneal
author Rodriguez, Cintia Pamela
Firpo, Camila Ayelén
Lazarte, Yobana Delina
Capriotti, Jorge Pedro
author_facet Rodriguez, Cintia Pamela
Firpo, Camila Ayelén
Lazarte, Yobana Delina
Capriotti, Jorge Pedro
author_sort Rodriguez, Cintia Pamela
title Isolated third cranial nerve ophthalmoparesis, an atypical form of presentation in non-Hodgkin's lymphoma.: Ophthalmoparesis of the third cranial nerve a rare presentation in non-Hodgkins lymphoma
title_short Isolated third cranial nerve ophthalmoparesis, an atypical form of presentation in non-Hodgkin's lymphoma.: Ophthalmoparesis of the third cranial nerve a rare presentation in non-Hodgkins lymphoma
title_full Isolated third cranial nerve ophthalmoparesis, an atypical form of presentation in non-Hodgkin's lymphoma.: Ophthalmoparesis of the third cranial nerve a rare presentation in non-Hodgkins lymphoma
title_fullStr Isolated third cranial nerve ophthalmoparesis, an atypical form of presentation in non-Hodgkin's lymphoma.: Ophthalmoparesis of the third cranial nerve a rare presentation in non-Hodgkins lymphoma
title_full_unstemmed Isolated third cranial nerve ophthalmoparesis, an atypical form of presentation in non-Hodgkin's lymphoma.: Ophthalmoparesis of the third cranial nerve a rare presentation in non-Hodgkins lymphoma
title_sort isolated third cranial nerve ophthalmoparesis, an atypical form of presentation in non-hodgkin's lymphoma.: ophthalmoparesis of the third cranial nerve a rare presentation in non-hodgkins lymphoma
description We present a patient with non-Hodgkin's lymphoma with isolated ophthalmoparesis of the III cranial pair. We describe the clinical, radiological and analytical characteristics of the cerebrospinal fluid that made the diagnosis difficult, in a 55-year-old man with C virus carriage, hepatocarcinoma in remission and ethylism. He presented with isolated right third cranial nerve palsy, with pupillary involvement. The initial MRI showed increased thickness and enhancement of this nerve. Cerebrospinal fluid analysis showed no pathological findings. In the following months, due to clinical progression, the MRI was repeated and showed evidence of extension of the lesion. New CSF samples showed pleocytosis and hyperproteinorrachia, with negative cytology, cultures and flow cytometry. A biopsy was decided which revealed type B non-Hodgkin's lymphoma. We conducted a literature search where we found to date 12 cases of isolated paralysis of the third pair as clinical presentation of this type of lymphoma, being a rare form and to be considered in certain patients.
publisher Universidad Nacional de Rosario
publishDate 2025
url https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/117
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first_indexed 2025-09-04T05:06:38Z
last_indexed 2025-09-04T05:06:38Z
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