Empleo de un modelo murino original de Argentina en la caracterización de fenotipos complejos

The laboratory mouse (Mus musculus) is a species widely used as a model organism in diverse areas of Biology. This species is considered an almost perfect model system because of its short generation interval, simple breeding strategies and high biotic potential; these, as well as other characteri...

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Detalles Bibliográficos
Autores principales: Hinrichsen, Lucila Isabel, Di Masso, Ricardo José
Formato: article artículo publishedVersion
Lenguaje:Español
Publicado: Sociedad Argentina de Genética 2017
Materias:
murine model
growth
parasitosis
mammary carcinogenesis
Acceso en línea:http://hdl.handle.net/2133/9387
http://hdl.handle.net/2133/9387
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-9387
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Español
orig_language_str_mv spa
topic murine model
growth
parasitosis
mammary carcinogenesis
spellingShingle murine model
growth
parasitosis
mammary carcinogenesis
Hinrichsen, Lucila Isabel
Di Masso, Ricardo José
Empleo de un modelo murino original de Argentina en la caracterización de fenotipos complejos
topic_facet murine model
growth
parasitosis
mammary carcinogenesis
description The laboratory mouse (Mus musculus) is a species widely used as a model organism in diverse areas of Biology. This species is considered an almost perfect model system because of its short generation interval, simple breeding strategies and high biotic potential; these, as well as other characteristics, make the mouse an almost unique resource in experimental genetics. The Instituto de Genética Experimental, Facultad de Ciencias Médicas, Universidad Nacional de Rosario developed several lines of mice in long-term divergent selection experiments on body conformation. Due to the joint effects of selective breeding for more than 100 generations, a correlated response to selection, non-directional effects of inbreeding and genetic drift, and the appearance of new mutations, each line fixed different allelic combinations. Morphometric studies of the hemimandible and the femur corroborated the feature of singular genotype attributed to each line. This is why the lines of this colony became an attractive murine model to study complex genetic traits such as growth, development and body composition, muscle contractile properties, resistance to parasitosis, susceptibility to mammary spontaneous carcinogenesis as well as the influence of the host on the growth of a transplantable mammary adenocarcinoma. The results obtained demonstrate that these lines are a source of significant genetic variance in all the characters analyzed.
format article
artículo
publishedVersion
author Hinrichsen, Lucila Isabel
Di Masso, Ricardo José
author_facet Hinrichsen, Lucila Isabel
Di Masso, Ricardo José
author_sort Hinrichsen, Lucila Isabel
title Empleo de un modelo murino original de Argentina en la caracterización de fenotipos complejos
title_short Empleo de un modelo murino original de Argentina en la caracterización de fenotipos complejos
title_full Empleo de un modelo murino original de Argentina en la caracterización de fenotipos complejos
title_fullStr Empleo de un modelo murino original de Argentina en la caracterización de fenotipos complejos
title_full_unstemmed Empleo de un modelo murino original de Argentina en la caracterización de fenotipos complejos
title_sort empleo de un modelo murino original de argentina en la caracterización de fenotipos complejos
publisher Sociedad Argentina de Genética
publishDate 2017
url http://hdl.handle.net/2133/9387
http://hdl.handle.net/2133/9387
work_keys_str_mv AT hinrichsenlucilaisabel empleodeunmodelomurinooriginaldeargentinaenlacaracterizaciondefenotiposcomplejos
AT dimassoricardojose empleodeunmodelomurinooriginaldeargentinaenlacaracterizaciondefenotiposcomplejos
bdutipo_str Repositorios
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