The Influence of Sex Steroid Hormones in the Immunopathology of Experimental Pulmonary Tuberculosis

The relation between men and women suffering pulmonary tuberculosis is 7/3 in favor to males. Sex hormones could be a significant factor for this difference, considering that testosterone impairs macrophage activation and pro-inflammatory cytokines production, while estrogens are proinflammatory med...

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Detalles Bibliográficos
Autores principales: Bini, Estela Isabel, Espinosa, Dulce Mata, Castillo, Brenda Marquina, Payán, Jorge Barrios, Colucci, Darío, Cruz, Alejandro Francisco, Zatarain, Zyanya Lucía, Alfonseca, Edgar, Romano Pardo, Marta, Bottasso, Oscar, Hernández Pando, Rogelio
Formato: artículo publishedVersion article
Lenguaje:Inglés
Publicado: PLOS (Public Library of Science) 2014
Materias:
Tuberculosis
Testosterone
Pneumonia
Mycobacterium tuberculosis
Inflammatory diseases
Inflammation
Granulomas
Cytokines
Acceso en línea:http://hdl.handle.net/2133/3268
http://hdl.handle.net/2133/3268
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-3268
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Tuberculosis
Testosterone
Pneumonia
Mycobacterium tuberculosis
Inflammatory diseases
Inflammation
Granulomas
Cytokines
spellingShingle Tuberculosis
Testosterone
Pneumonia
Mycobacterium tuberculosis
Inflammatory diseases
Inflammation
Granulomas
Cytokines
Bini, Estela Isabel
Espinosa, Dulce Mata
Castillo, Brenda Marquina
Payán, Jorge Barrios
Colucci, Darío
Cruz, Alejandro Francisco
Zatarain, Zyanya Lucía
Alfonseca, Edgar
Romano Pardo, Marta
Bottasso, Oscar
Hernández Pando, Rogelio
The Influence of Sex Steroid Hormones in the Immunopathology of Experimental Pulmonary Tuberculosis
topic_facet Tuberculosis
Testosterone
Pneumonia
Mycobacterium tuberculosis
Inflammatory diseases
Inflammation
Granulomas
Cytokines
description The relation between men and women suffering pulmonary tuberculosis is 7/3 in favor to males. Sex hormones could be a significant factor for this difference, considering that testosterone impairs macrophage activation and pro-inflammatory cytokines production, while estrogens are proinflammatory mediator’s inducer. The aim of this work was to compare the evolution of tuberculosis in male and female mice using a model of progressive disease. BALB/c mice, male and female were randomized into two groups: castrated or sham-operated, and infected by the intratracheal route with a high dose of Mycobacterium tuberculosis strain H37Rv. Mice were euthanized at different time points and in their lungs were determined bacilli loads, inflammation, cytokines expression, survival and testosterone levels in serum. Non-castrated male mice showed significant higher mortality and bacilli burdens during late disease than female and castrated male animals. Compared to males, females and castrated males exhibited significant higher inflammation in all lung compartments, earlier formation of granulomas and pneumonia, while between castrated and non-castrated females there were not significant differences. Females and castrated males expressed significant higher TNF-α, IFN γ, IL12, iNOS and IL17 than non-castrated males during the first month of infection. Serum Testosterone of males showed higher concentration during late infection. Orchidectomy at day 60 post-infection produced a significant decrease of bacilli burdens in coexistence with higher expression of TNFα, IL-12 and IFNγ. Thus, male mice are more susceptible to tuberculosis than females and this was prevented by castration suggesting that testosterone could be a tuberculosis susceptibility factor.
format artículo
publishedVersion
article
author Bini, Estela Isabel
Espinosa, Dulce Mata
Castillo, Brenda Marquina
Payán, Jorge Barrios
Colucci, Darío
Cruz, Alejandro Francisco
Zatarain, Zyanya Lucía
Alfonseca, Edgar
Romano Pardo, Marta
Bottasso, Oscar
Hernández Pando, Rogelio
author_facet Bini, Estela Isabel
Espinosa, Dulce Mata
Castillo, Brenda Marquina
Payán, Jorge Barrios
Colucci, Darío
Cruz, Alejandro Francisco
Zatarain, Zyanya Lucía
Alfonseca, Edgar
Romano Pardo, Marta
Bottasso, Oscar
Hernández Pando, Rogelio
author_sort Bini, Estela Isabel
title The Influence of Sex Steroid Hormones in the Immunopathology of Experimental Pulmonary Tuberculosis
title_short The Influence of Sex Steroid Hormones in the Immunopathology of Experimental Pulmonary Tuberculosis
title_full The Influence of Sex Steroid Hormones in the Immunopathology of Experimental Pulmonary Tuberculosis
title_fullStr The Influence of Sex Steroid Hormones in the Immunopathology of Experimental Pulmonary Tuberculosis
title_full_unstemmed The Influence of Sex Steroid Hormones in the Immunopathology of Experimental Pulmonary Tuberculosis
title_sort influence of sex steroid hormones in the immunopathology of experimental pulmonary tuberculosis
publisher PLOS (Public Library of Science)
publishDate 2014
url http://hdl.handle.net/2133/3268
http://hdl.handle.net/2133/3268
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