Assessment of Cross-reactive Host-pathogen Antibodies in Patients With Different Stages of Chronic Chagas Disease
Introduction and objectives Trypanosoma cruzi infection has been shown to induce humoral autoimmune responses against host antigens tissues. Particularly, antibodies cross-reacting with myocardial antigens may play a role in the development of the severe forms of chronic Chagas disease. The aim of...
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| Autores principales: | , , , , , , , , , |
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| Formato: | artículo publishedVersion article |
| Lenguaje: | Inglés |
| Publicado: |
Sociedad Española de Cardiología
2014
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| Acceso en línea: | http://hdl.handle.net/2133/2841 http://hdl.handle.net/2133/2841 |
| Aporte de: |
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I15-R121-2133-2841 |
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| record_format |
dspace |
| institution |
Universidad Nacional de Rosario |
| institution_str |
I-15 |
| repository_str |
R-121 |
| collection |
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) |
| language |
Inglés |
| orig_language_str_mv |
en |
| topic |
Chagas disease Trypanosoma cruzi Heart failure Anti-B13 autoantibodies Enfermedad de Chagas Insuficiencia cardiaca Autoanticuerpos anti-B13 |
| spellingShingle |
Chagas disease Trypanosoma cruzi Heart failure Anti-B13 autoantibodies Enfermedad de Chagas Insuficiencia cardiaca Autoanticuerpos anti-B13 Vicco, Miguel H. Ferini, Franco Rodeles, Luz Cardona, Paula Bontempi, Iván Lioi, Susana Beloscar, Juan Nara, Takeshi Marcipar, Iván Bottasso, Oscar Assessment of Cross-reactive Host-pathogen Antibodies in Patients With Different Stages of Chronic Chagas Disease |
| topic_facet |
Chagas disease Trypanosoma cruzi Heart failure Anti-B13 autoantibodies Enfermedad de Chagas Insuficiencia cardiaca Autoanticuerpos anti-B13 |
| description |
Introduction and objectives
Trypanosoma cruzi infection has been shown to induce humoral autoimmune responses against host antigens tissues. Particularly, antibodies cross-reacting with myocardial antigens may play a role in the development of the severe forms of chronic Chagas disease. The aim of this study was to determine the association between clinical stage of the disease and the presence of autoantibodies in patients with chronic Chagasic disease.
Methods
We performed a cross-sectional study in T. cruzi-seropositive patients divided into 3 groups according to the classic classification of chronic Chagas heart of Storino et al. All participants underwent complete clinical examination and their sera were used to measure autoantibody levels.
Results
All patients had detectable levels of anti-p2β and anti-B13 autoantibodies but none had anti-Na-K-ATPase antibodies. No association was observed between electrocardiographic conduction disturbances and autoantibody levels. Patients with chronic Chagas disease stage III had the highest levels of anti-B13 antibodies and a high risk of mortality score, showing a clear association between disease stage and this score.
Conclusions
Anti-B13 antibodies were significantly higher in chronic Chagas disease stage III patients, suggesting that these antibodies may be involved in disease progression and that they might be a useful marker of poor prognosis in terms of heart compromise. Our results also reveal an important correlation between the level of anti-B13 autoantibodies and symptomatic heart failure and/or dilated cardiomyopathy. |
| format |
artículo publishedVersion article |
| author |
Vicco, Miguel H. Ferini, Franco Rodeles, Luz Cardona, Paula Bontempi, Iván Lioi, Susana Beloscar, Juan Nara, Takeshi Marcipar, Iván Bottasso, Oscar |
| author_facet |
Vicco, Miguel H. Ferini, Franco Rodeles, Luz Cardona, Paula Bontempi, Iván Lioi, Susana Beloscar, Juan Nara, Takeshi Marcipar, Iván Bottasso, Oscar |
| author_sort |
Vicco, Miguel H. |
| title |
Assessment of Cross-reactive Host-pathogen Antibodies in Patients With Different Stages of Chronic Chagas Disease |
| title_short |
Assessment of Cross-reactive Host-pathogen Antibodies in Patients With Different Stages of Chronic Chagas Disease |
| title_full |
Assessment of Cross-reactive Host-pathogen Antibodies in Patients With Different Stages of Chronic Chagas Disease |
| title_fullStr |
Assessment of Cross-reactive Host-pathogen Antibodies in Patients With Different Stages of Chronic Chagas Disease |
| title_full_unstemmed |
Assessment of Cross-reactive Host-pathogen Antibodies in Patients With Different Stages of Chronic Chagas Disease |
| title_sort |
assessment of cross-reactive host-pathogen antibodies in patients with different stages of chronic chagas disease |
| publisher |
Sociedad Española de Cardiología |
| publishDate |
2014 |
| url |
http://hdl.handle.net/2133/2841 http://hdl.handle.net/2133/2841 |
| work_keys_str_mv |
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Repositorios |
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