Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents

Twenty-five polysubstituted phthalazinone derivatives were synthesized and tested for their antifungal activity against a panel of pathogenic and clinically important yeasts and filamentous fungi. Among them, the compound 4-(4-chlorobenzyl)-2- methylphthalazin-1(2H)-one (5) exhibited a remarkable...

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Autores principales:	Derita, Marcos, del Olmo, Esther, Barboza, Bianca, García-Cadenas, Ana E., López-Pérez, José L., Andújar, Sebastián, Enriz, Daniel, Zacchino, Susana, San Feliciano, Arturo
Formato:	article artículo publishedVersion
Lenguaje:	Inglés
Publicado:	MDPI Open Access Publishing 2013
Materias:	benzylphthalazinones antifungal Cryptococcus neoformans dermatophytes structure–activity relationships conformational study
Acceso en línea:	http://hdl.handle.net/2133/2584 http://hdl.handle.net/2133/2584
Aporte de:	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario

id	I15-R121-2133-2584
record_format	dspace
institution	Universidad Nacional de Rosario
institution_str	I-15
repository_str	R-121
collection	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language	Inglés
orig_language_str_mv	en
topic	benzylphthalazinones antifungal Cryptococcus neoformans dermatophytes structure–activity relationships conformational study
spellingShingle	benzylphthalazinones antifungal Cryptococcus neoformans dermatophytes structure–activity relationships conformational study Derita, Marcos del Olmo, Esther Barboza, Bianca García-Cadenas, Ana E. López-Pérez, José L. Andújar, Sebastián Enriz, Daniel Zacchino, Susana San Feliciano, Arturo Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents
topic_facet	benzylphthalazinones antifungal Cryptococcus neoformans dermatophytes structure–activity relationships conformational study
description	Twenty-five polysubstituted phthalazinone derivatives were synthesized and tested for their antifungal activity against a panel of pathogenic and clinically important yeasts and filamentous fungi. Among them, the compound 4-(4-chlorobenzyl)-2- methylphthalazin-1(2H)-one (5) exhibited a remarkable antifungal activity against standardised strains of dermatophytes and Cryptococcus neoformans, as well as against some clinical isolates. A physicochemical study performed on compound 5 revealed its conformational and electronic characteristics, providing us with useful data for the future design of novel related antifungal analogues.
format	article artículo publishedVersion
author	Derita, Marcos del Olmo, Esther Barboza, Bianca García-Cadenas, Ana E. López-Pérez, José L. Andújar, Sebastián Enriz, Daniel Zacchino, Susana San Feliciano, Arturo
author_facet	Derita, Marcos del Olmo, Esther Barboza, Bianca García-Cadenas, Ana E. López-Pérez, José L. Andújar, Sebastián Enriz, Daniel Zacchino, Susana San Feliciano, Arturo
author_sort	Derita, Marcos
title	Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents
title_short	Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents
title_full	Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents
title_fullStr	Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents
title_full_unstemmed	Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents
title_sort	synthesis, bioevaluation and structural study of substituted phthalazin-1(2h)-ones acting as antifungal agents
publisher	MDPI Open Access Publishing
publishDate	2013
url	http://hdl.handle.net/2133/2584 http://hdl.handle.net/2133/2584
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bdutipo_str	Repositorios
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Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents

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