Update on the biological relevance of lysine acetylation as a novel drug target in trypanosomatids
The number of acetylated proteins identified from bacteria to mammals has grown exponentially in the last ten years and it is now accepted that acetylation is a key component in most eukaryotic signaling pathways, as important as phosphorylation. The enzymes involved in this process are well desc...
Guardado en:
| Autores principales: | , , |
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| Lenguaje: | Inglés |
| Publicado: |
Bentham Science Publishers
2023
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/2133/25132 http://hdl.handle.net/2133/25132 |
| Aporte de: |
| id |
I15-R121-2133-25132 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de Rosario |
| institution_str |
I-15 |
| repository_str |
R-121 |
| collection |
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) |
| language |
Inglés |
| topic |
Acetylation Acetyltransferases Deacetylases Acetylome Trypanosomatids Cytoskeleton |
| spellingShingle |
Acetylation Acetyltransferases Deacetylases Acetylome Trypanosomatids Cytoskeleton Martinez Peralta, Gonzalo Serra, Esteban C. Alonso, Victoria Lucía Update on the biological relevance of lysine acetylation as a novel drug target in trypanosomatids |
| topic_facet |
Acetylation Acetyltransferases Deacetylases Acetylome Trypanosomatids Cytoskeleton |
| description |
The number of acetylated proteins identified from bacteria to mammals has grown
exponentially in the last ten years and it is now accepted that acetylation is a key component in most
eukaryotic signaling pathways, as important as phosphorylation. The enzymes involved in this process
are well described in mammals; acetyltransferases and deacetylases are found inside and outside the
nuclear compartment and have different regulatory functions. In trypanosomatids several of these
enzymes have been described and are postulated to be novel antiparasitic targets for the rational design
of drugs. In this review article we present an update of the most important known acetylated proteins in
trypanosomatids analyzing the acetylomes available. Also, we summarize the information available
regarding acetyltransferases and deacetylases in trypanosomes and their potential use as
chemotherapeutic targets. |
| author |
Martinez Peralta, Gonzalo Serra, Esteban C. Alonso, Victoria Lucía |
| author_facet |
Martinez Peralta, Gonzalo Serra, Esteban C. Alonso, Victoria Lucía |
| author_sort |
Martinez Peralta, Gonzalo |
| title |
Update on the biological relevance of lysine acetylation as a novel drug target in trypanosomatids |
| title_short |
Update on the biological relevance of lysine acetylation as a novel drug target in trypanosomatids |
| title_full |
Update on the biological relevance of lysine acetylation as a novel drug target in trypanosomatids |
| title_fullStr |
Update on the biological relevance of lysine acetylation as a novel drug target in trypanosomatids |
| title_full_unstemmed |
Update on the biological relevance of lysine acetylation as a novel drug target in trypanosomatids |
| title_sort |
update on the biological relevance of lysine acetylation as a novel drug target in trypanosomatids |
| publisher |
Bentham Science Publishers |
| publishDate |
2023 |
| url |
http://hdl.handle.net/2133/25132 http://hdl.handle.net/2133/25132 |
| work_keys_str_mv |
AT martinezperaltagonzalo updateonthebiologicalrelevanceoflysineacetylationasanoveldrugtargetintrypanosomatids AT serraestebanc updateonthebiologicalrelevanceoflysineacetylationasanoveldrugtargetintrypanosomatids AT alonsovictorialucia updateonthebiologicalrelevanceoflysineacetylationasanoveldrugtargetintrypanosomatids |
| bdutipo_str |
Repositorios |
| _version_ |
1764820412739354627 |