Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress

The balances between NSCs growth and differentiation, and between glial and neuronal differentiation play a key role in brain regeneration after any pathological conditions. It is well known that the nervous tissue shows a poor recovery after injury due to the factors present in the wounded microenv...

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Autores principales: Magaquian, Dario, Delgado Ocaña, Susana, Perez, Consuelo, Banchio, Claudia
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: Nature Research 2022
Materias:
Cell Plasticity
Neural Stem Cells
Inflammation Mediators
Phosphatidylcholines
Neuroinflammatory Diseases
Acceso en línea:http://hdl.handle.net/2133/23638
http://hdl.handle.net/2133/23638
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-23638
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Cell Plasticity
Neural Stem Cells
Inflammation Mediators
Phosphatidylcholines
Neuroinflammatory Diseases
spellingShingle Cell Plasticity
Neural Stem Cells
Inflammation Mediators
Phosphatidylcholines
Neuroinflammatory Diseases
Magaquian, Dario
Delgado Ocaña, Susana
Perez, Consuelo
Banchio, Claudia
Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress
topic_facet Cell Plasticity
Neural Stem Cells
Inflammation Mediators
Phosphatidylcholines
Neuroinflammatory Diseases
description The balances between NSCs growth and differentiation, and between glial and neuronal differentiation play a key role in brain regeneration after any pathological conditions. It is well known that the nervous tissue shows a poor recovery after injury due to the factors present in the wounded microenvironment, particularly inflammatory factors, that prevent neuronal differentiation. Thus, it is essential to generate a favourable condition for NSCs and conduct them to differentiate towards functional neurons. Here, we show that neuroinflammation has no effect on NSCs proliferation but induces an aberrant neuronal differentiation that gives rise to dystrophic, non-functional neurons. This is perhaps the initial step of brain failure associated to many neurological disorders. Interestingly, we demonstrate that phosphatidylcholine (PtdCho)-enriched media enhances neuronal differentiation even under inflammatory stress by modifying the commitment of post-mitotic cells. The proneurogenic effect of PtdCho increases the population of healthy normal neurons. In addition, we provide evidences that this phospholipid ameliorates the damage of neurons and, in consequence, modulates neuronal plasticity. These results contribute to our understanding of NSCs behaviour under inflammatory conditions, opening up new venues to improve neurogenic capacity in the brain.
format article
artículo
publishedVersion
author Magaquian, Dario
Delgado Ocaña, Susana
Perez, Consuelo
Banchio, Claudia
author_facet Magaquian, Dario
Delgado Ocaña, Susana
Perez, Consuelo
Banchio, Claudia
author_sort Magaquian, Dario
title Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress
title_short Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress
title_full Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress
title_fullStr Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress
title_full_unstemmed Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress
title_sort phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress
publisher Nature Research
publishDate 2022
url http://hdl.handle.net/2133/23638
http://hdl.handle.net/2133/23638
work_keys_str_mv AT magaquiandario phosphatidylcholinerestoresneuronalplasticityofneuralstemcellsunderinflammatorystress
AT delgadoocanasusana phosphatidylcholinerestoresneuronalplasticityofneuralstemcellsunderinflammatorystress
AT perezconsuelo phosphatidylcholinerestoresneuronalplasticityofneuralstemcellsunderinflammatorystress
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bdutipo_str Repositorios
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