Cyclodextrin-modified nanomaterials for drug delivery: Classification and advances in controlled release and bioavailability

In drug delivery, one widely used way of overcoming the biopharmaceutical problems present in several active pharmaceutical ingredients, such as poor aqueous solubility, early instability, and low bioavailability, is the formation of inclusion compounds with cyclodextrins (CD). In recent years, the...

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Detalles Bibliográficos
Autores principales: Real, Daniel Andrés, Bolaños, Karen, Priotti, Josefina, Yutronic, Nicolás, Kogan, Marcelo J., Sierpe, Rodrigo, Donoso González, Orlando
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: MDPI 2022
Materias:
Cyclodextrins derivatives
Drug delivery
Nanomaterials
Nanoparticles
Polymers
Controlled release
Bioavailability
Acceso en línea:http://hdl.handle.net/2133/23374
http://hdl.handle.net/2133/23374
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-23374
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Cyclodextrins derivatives
Drug delivery
Nanomaterials
Nanoparticles
Polymers
Controlled release
Bioavailability
spellingShingle Cyclodextrins derivatives
Drug delivery
Nanomaterials
Nanoparticles
Polymers
Controlled release
Bioavailability
Real, Daniel Andrés
Bolaños, Karen
Priotti, Josefina
Yutronic, Nicolás
Kogan, Marcelo J.
Sierpe, Rodrigo
Donoso González, Orlando
Cyclodextrin-modified nanomaterials for drug delivery: Classification and advances in controlled release and bioavailability
topic_facet Cyclodextrins derivatives
Drug delivery
Nanomaterials
Nanoparticles
Polymers
Controlled release
Bioavailability
description In drug delivery, one widely used way of overcoming the biopharmaceutical problems present in several active pharmaceutical ingredients, such as poor aqueous solubility, early instability, and low bioavailability, is the formation of inclusion compounds with cyclodextrins (CD). In recent years, the use of CD derivatives in combination with nanomaterials has shown to be a promising strategy for formulating new, optimized systems. The goals of this review are to give in-depth knowledge and critical appraisal of the main CD-modified or CD-based nanomaterials for drug delivery, such as lipid-based nanocarriers, natural and synthetic polymeric nanocarriers, nanosponges, graphene derivatives, mesoporous silica nanoparticles, plasmonic and magnetic nanoparticles, quantum dots and other miscellaneous systems such as nanovalves, metal-organic frameworks, Janus nanoparticles, and nanofibers. Special attention is given to nanosystems that achieve controlled drug release and increase their bioavailability during in vivo studies.
format article
artículo
publishedVersion
author Real, Daniel Andrés
Bolaños, Karen
Priotti, Josefina
Yutronic, Nicolás
Kogan, Marcelo J.
Sierpe, Rodrigo
Donoso González, Orlando
author_facet Real, Daniel Andrés
Bolaños, Karen
Priotti, Josefina
Yutronic, Nicolás
Kogan, Marcelo J.
Sierpe, Rodrigo
Donoso González, Orlando
author_sort Real, Daniel Andrés
title Cyclodextrin-modified nanomaterials for drug delivery: Classification and advances in controlled release and bioavailability
title_short Cyclodextrin-modified nanomaterials for drug delivery: Classification and advances in controlled release and bioavailability
title_full Cyclodextrin-modified nanomaterials for drug delivery: Classification and advances in controlled release and bioavailability
title_fullStr Cyclodextrin-modified nanomaterials for drug delivery: Classification and advances in controlled release and bioavailability
title_full_unstemmed Cyclodextrin-modified nanomaterials for drug delivery: Classification and advances in controlled release and bioavailability
title_sort cyclodextrin-modified nanomaterials for drug delivery: classification and advances in controlled release and bioavailability
publisher MDPI
publishDate 2022
url http://hdl.handle.net/2133/23374
http://hdl.handle.net/2133/23374
work_keys_str_mv AT realdanielandres cyclodextrinmodifiednanomaterialsfordrugdeliveryclassificationandadvancesincontrolledreleaseandbioavailability
AT bolanoskaren cyclodextrinmodifiednanomaterialsfordrugdeliveryclassificationandadvancesincontrolledreleaseandbioavailability
AT priottijosefina cyclodextrinmodifiednanomaterialsfordrugdeliveryclassificationandadvancesincontrolledreleaseandbioavailability
AT yutronicnicolas cyclodextrinmodifiednanomaterialsfordrugdeliveryclassificationandadvancesincontrolledreleaseandbioavailability
AT koganmarceloj cyclodextrinmodifiednanomaterialsfordrugdeliveryclassificationandadvancesincontrolledreleaseandbioavailability
AT sierperodrigo cyclodextrinmodifiednanomaterialsfordrugdeliveryclassificationandadvancesincontrolledreleaseandbioavailability
AT donosogonzalezorlando cyclodextrinmodifiednanomaterialsfordrugdeliveryclassificationandadvancesincontrolledreleaseandbioavailability
bdutipo_str Repositorios
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