New Alkaloids From a Hawaiian Fungal Strain Aspergillus felis FM324

Two new alkaloids tryptoquivaline Y (1) and pseurotin I (2), together with eight known compounds (3–10), were purified from a fungal strain Aspergillus felis FM324, which was isolated from a Hawaiian beach soil sample. The absolute configuration and physicochemical data of tryptoquivaline Z (3) w...

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Autores principales: Wang, Cong, Sarotti, Ariel Marcelo, Uz Zaman, Ahammad, Wu, Xiaohua, Cao, Shugeng
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: Frontiers Media 2022
Materias:
Aspergillus felis
Trichocomaceae
Alkaloids
Antiproliferative
Antibacterial
NF-κB inhibitory activities
Acceso en línea:http://hdl.handle.net/2133/23266
http://hdl.handle.net/2133/23266
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-23266
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Aspergillus felis
Trichocomaceae
Alkaloids
Antiproliferative
Antibacterial
NF-κB inhibitory activities
spellingShingle Aspergillus felis
Trichocomaceae
Alkaloids
Antiproliferative
Antibacterial
NF-κB inhibitory activities
Wang, Cong
Sarotti, Ariel Marcelo
Uz Zaman, Ahammad
Wu, Xiaohua
Cao, Shugeng
New Alkaloids From a Hawaiian Fungal Strain Aspergillus felis FM324
topic_facet Aspergillus felis
Trichocomaceae
Alkaloids
Antiproliferative
Antibacterial
NF-κB inhibitory activities
description Two new alkaloids tryptoquivaline Y (1) and pseurotin I (2), together with eight known compounds (3–10), were purified from a fungal strain Aspergillus felis FM324, which was isolated from a Hawaiian beach soil sample. The absolute configuration and physicochemical data of tryptoquivaline Z (3) were reported for the first time here in this paper. Compound 1 is an uncommon tryptoquivaline analog containing a 3-Oisobutanoyl group. The structures of the new compounds 1–2 and known compound 3 were elucidated through HRESIMS, NMR spectroscopy and ECD analysis. All the compounds were evaluated for their antiproliferative, antibacterial and NF-κB inhibitory activities. Compound 4 showed weak antibacterial activity against Staphylococcus aureus, methicillin resistant Staphylococcus aureus and Bacillus subtilis with the same MIC value of 59.2 µM. Compounds 3 and 2 inhibited NF-κB with IC50 values of 26.7 and 30.9 μM, respectively.
format article
artículo
publishedVersion
author Wang, Cong
Sarotti, Ariel Marcelo
Uz Zaman, Ahammad
Wu, Xiaohua
Cao, Shugeng
author_facet Wang, Cong
Sarotti, Ariel Marcelo
Uz Zaman, Ahammad
Wu, Xiaohua
Cao, Shugeng
author_sort Wang, Cong
title New Alkaloids From a Hawaiian Fungal Strain Aspergillus felis FM324
title_short New Alkaloids From a Hawaiian Fungal Strain Aspergillus felis FM324
title_full New Alkaloids From a Hawaiian Fungal Strain Aspergillus felis FM324
title_fullStr New Alkaloids From a Hawaiian Fungal Strain Aspergillus felis FM324
title_full_unstemmed New Alkaloids From a Hawaiian Fungal Strain Aspergillus felis FM324
title_sort new alkaloids from a hawaiian fungal strain aspergillus felis fm324
publisher Frontiers Media
publishDate 2022
url http://hdl.handle.net/2133/23266
http://hdl.handle.net/2133/23266
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AT wuxiaohua newalkaloidsfromahawaiianfungalstrainaspergillusfelisfm324
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