N-heterocyclic carbene iron complexes as anticancer agents: In vitro and in vivo biological studies

Cisplatin and its derivatives are commonly used in chemotherapeutic treatments of cancer, even though they suffer from many toxic side effects. The problems that emerge from the use of these metal compounds led to the search for new complexes capable to overcome the toxic side effects. Here, we repo...

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Autores principales:	Lenis-Rojas, Oscar A., Cordeiro, Sandra, Horta-Meireles, Marta, Araujo Fernández, Jhonathan Angel, Fernández Vila, Sabela, Rubiolo, Juan Andrés, Cabezas-Sainz, Pablo, Sanchez, Laura, Fernandes, Alexandra R., Royo, Beatriz
Formato:	article artículo publishedVersion
Lenguaje:	Inglés
Publicado:	MDPI 2022
Materias:	N-heterocyclic carbene Iron(II)–NHC complexes Anticancer activity Zebrafish
Acceso en línea:	http://hdl.handle.net/2133/23256 http://hdl.handle.net/2133/23256
Aporte de:	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario

id	I15-R121-2133-23256
record_format	dspace
institution	Universidad Nacional de Rosario
institution_str	I-15
repository_str	R-121
collection	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language	Inglés
orig_language_str_mv	eng
topic	N-heterocyclic carbene Iron(II)–NHC complexes Anticancer activity Zebrafish
spellingShingle	N-heterocyclic carbene Iron(II)–NHC complexes Anticancer activity Zebrafish Lenis-Rojas, Oscar A. Cordeiro, Sandra Horta-Meireles, Marta Araujo Fernández, Jhonathan Angel Fernández Vila, Sabela Rubiolo, Juan Andrés Cabezas-Sainz, Pablo Sanchez, Laura Fernandes, Alexandra R. Royo, Beatriz N-heterocyclic carbene iron complexes as anticancer agents: In vitro and in vivo biological studies
topic_facet	N-heterocyclic carbene Iron(II)–NHC complexes Anticancer activity Zebrafish
description	Cisplatin and its derivatives are commonly used in chemotherapeutic treatments of cancer, even though they suffer from many toxic side effects. The problems that emerge from the use of these metal compounds led to the search for new complexes capable to overcome the toxic side effects. Here, we report the evaluation of the antiproliferative activity of Fe(II) cyclopentadienyl complexes bearing n-heterocyclic carbene ligands in tumour cells and their in vivo toxicological profile. The in vitro antiproliferative assays demonstrated that complex Fe1 displays the highest cytotoxic activity both in human colorectal carcinoma cells (HCT116) and ovarian carcinoma cells (A2780) with IC50 values in the low micromolar range. The antiproliferative effect of Fe1 was even higher than cisplatin. Interestingly, Fe1 showed low in vivo toxicity, and in vivo analyses of Fe1 and Fe2 compounds using colorectal HCT116 zebrafish xenograft showed that both reduce the proliferation of human HCT116 colorectal cancer cells in vivo.
format	article artículo publishedVersion
author	Lenis-Rojas, Oscar A. Cordeiro, Sandra Horta-Meireles, Marta Araujo Fernández, Jhonathan Angel Fernández Vila, Sabela Rubiolo, Juan Andrés Cabezas-Sainz, Pablo Sanchez, Laura Fernandes, Alexandra R. Royo, Beatriz
author_facet	Lenis-Rojas, Oscar A. Cordeiro, Sandra Horta-Meireles, Marta Araujo Fernández, Jhonathan Angel Fernández Vila, Sabela Rubiolo, Juan Andrés Cabezas-Sainz, Pablo Sanchez, Laura Fernandes, Alexandra R. Royo, Beatriz
author_sort	Lenis-Rojas, Oscar A.
title	N-heterocyclic carbene iron complexes as anticancer agents: In vitro and in vivo biological studies
title_short	N-heterocyclic carbene iron complexes as anticancer agents: In vitro and in vivo biological studies
title_full	N-heterocyclic carbene iron complexes as anticancer agents: In vitro and in vivo biological studies
title_fullStr	N-heterocyclic carbene iron complexes as anticancer agents: In vitro and in vivo biological studies
title_full_unstemmed	N-heterocyclic carbene iron complexes as anticancer agents: In vitro and in vivo biological studies
title_sort	n-heterocyclic carbene iron complexes as anticancer agents: in vitro and in vivo biological studies
publisher	MDPI
publishDate	2022
url	http://hdl.handle.net/2133/23256 http://hdl.handle.net/2133/23256
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bdutipo_str	Repositorios
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N-heterocyclic carbene iron complexes as anticancer agents: In vitro and in vivo biological studies

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