Effects of 2,4-dichlorophenoxyacetic acid on the ventral prostate of rats during the peri-pubertal, pubertal and adult stage

The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is used on a wide variety of terrestrial and aquatic broadleaf weeds. 2,4-D has been shown to produce a wide range of adverse effects on animal and human health. The aim of the current study was to evaluate the effects of pre- and postnatal exposu...

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Autores principales: Pochettino, Arístides A., Hapon, María Belén, Biolatto, Silvana M., Madariaga, María José, Jahn, Graciela A., Konjuh, Cintia N.
Formato: article artículo acceptedVersion
Lenguaje:Inglés
Publicado: Taylor and Francis 2021
Materias:
2,4-Dichlorophenoxyacetic herbicide
Developmental toxicity
Hormone
Androgen receptor
Acceso en línea:http://hdl.handle.net/2133/21332
http://hdl.handle.net/2133/21332
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-21332
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic 2,4-Dichlorophenoxyacetic herbicide
Developmental toxicity
Hormone
Androgen receptor
spellingShingle 2,4-Dichlorophenoxyacetic herbicide
Developmental toxicity
Hormone
Androgen receptor
Pochettino, Arístides A.
Hapon, María Belén
Biolatto, Silvana M.
Madariaga, María José
Jahn, Graciela A.
Konjuh, Cintia N.
Effects of 2,4-dichlorophenoxyacetic acid on the ventral prostate of rats during the peri-pubertal, pubertal and adult stage
topic_facet 2,4-Dichlorophenoxyacetic herbicide
Developmental toxicity
Hormone
Androgen receptor
description The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is used on a wide variety of terrestrial and aquatic broadleaf weeds. 2,4-D has been shown to produce a wide range of adverse effects on animal and human health. The aim of the current study was to evaluate the effects of pre- and postnatal exposure to 2,4-D on rat ventral prostate (VP). Pregnant rats were exposed daily to oral doses of 70 mg/kg/day of 2,4-D from 16 days of gestation up to 23 days after delivery. Then, the treated groups (n = 8) were fed with a 2,4-D added diet until sacrificed by decapitation on postnatal day (PND) 45, 60, or 90. Morphometric studies were performed and androgen receptor (AR) protein levels in the VP were determined. AR, insulin-like growth factor-I (IGF-1) and insulin-like growth factor-I receptor (IGF-1R) mRNA expression in the VP along with testosterone (T), dihydroxytestosterone (DHT), growth hormone (GH) and IGF-1 serum levels were also determined to ascertain whether these parameters were differentially affected. Results of this study showed that 2,4-D exposure during gestation and until adulthood altered development of the prostate gland in male rats, delaying it at early ages while increasing its size in adults, indicate that 2,4-D could behave as endocrine disruptors (EDs).
format article
artículo
acceptedVersion
author Pochettino, Arístides A.
Hapon, María Belén
Biolatto, Silvana M.
Madariaga, María José
Jahn, Graciela A.
Konjuh, Cintia N.
author_facet Pochettino, Arístides A.
Hapon, María Belén
Biolatto, Silvana M.
Madariaga, María José
Jahn, Graciela A.
Konjuh, Cintia N.
author_sort Pochettino, Arístides A.
title Effects of 2,4-dichlorophenoxyacetic acid on the ventral prostate of rats during the peri-pubertal, pubertal and adult stage
title_short Effects of 2,4-dichlorophenoxyacetic acid on the ventral prostate of rats during the peri-pubertal, pubertal and adult stage
title_full Effects of 2,4-dichlorophenoxyacetic acid on the ventral prostate of rats during the peri-pubertal, pubertal and adult stage
title_fullStr Effects of 2,4-dichlorophenoxyacetic acid on the ventral prostate of rats during the peri-pubertal, pubertal and adult stage
title_full_unstemmed Effects of 2,4-dichlorophenoxyacetic acid on the ventral prostate of rats during the peri-pubertal, pubertal and adult stage
title_sort effects of 2,4-dichlorophenoxyacetic acid on the ventral prostate of rats during the peri-pubertal, pubertal and adult stage
publisher Taylor and Francis
publishDate 2021
url http://hdl.handle.net/2133/21332
http://hdl.handle.net/2133/21332
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