Trypanosoma cruzi High Mobility Group B (TcHMGB) can act as an inflammatory mediator on mammalian cells

When an infection occurs, the innate immune cells recognize Pathogen Associated Molec ular Patterns (PAMPs) through their Pattern Recognition Receptors. This triggers an inflammatory response intended to kill the foreign microbe. But inflammation can also be triggered by the recognition of endogen...

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Autores principales: Cribb, Pamela, Perdomo, Virginia Gabriela, Alonso, Victoria Lucía, Manarin, Romina, Barrios-Payán, Jorge, Marquina-Castillo, Brenda, Tavernelli, Luis, Hernández-Pando, Rogelio
Formato: publishedVersion
Lenguaje:Inglés
Publicado: Public Library of Science (PLOS) 2021
Materias:
High Mobility Group B Proteins
Trypanosoma cruzi
Damage-associated Molecular Patterns
Inflammation
Acceso en línea:http://hdl.handle.net/2133/20196
http://hdl.handle.net/2133/20196
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-20196
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic High Mobility Group B Proteins
Trypanosoma cruzi
Damage-associated Molecular Patterns
Inflammation
spellingShingle High Mobility Group B Proteins
Trypanosoma cruzi
Damage-associated Molecular Patterns
Inflammation
Cribb, Pamela
Perdomo, Virginia Gabriela
Alonso, Victoria Lucía
Manarin, Romina
Barrios-Payán, Jorge
Marquina-Castillo, Brenda
Tavernelli, Luis
Hernández-Pando, Rogelio
Trypanosoma cruzi High Mobility Group B (TcHMGB) can act as an inflammatory mediator on mammalian cells
topic_facet High Mobility Group B Proteins
Trypanosoma cruzi
Damage-associated Molecular Patterns
Inflammation
description When an infection occurs, the innate immune cells recognize Pathogen Associated Molec ular Patterns (PAMPs) through their Pattern Recognition Receptors. This triggers an inflammatory response intended to kill the foreign microbe. But inflammation can also be triggered by the recognition of endogenous molecules called “Danger (or Damage) Asso ciated Molecular Patterns” (DAMPs) that are released by damaged or necrotic cells to “ring the alarm” of the immune system that repair is needed, so some of them are also known as “alarmins”. High Mobility group box 1 protein (HMGB1) is a prototypical alar min molecule released by injured cells and it is also actively secreted by cells of the innate immune system in response to invasion as well as to sterile damage. Trypanosoma cruzi, the causal agent of Chagas Disease, has its own HMGB protein that we called TcHMGB. Using in vitro and in vivo experimental systems, we demonstrated for the first time that TcHMGB is able to mediate inflammation on mammalian cells, inducing the expression of both pro-inflammatory and anti-inflammatory cytokines. Our results suggest that the parasite´s protein could have a role in the immune response and the pathogenesis of Cha gas disease, probably overlapping to some extent with the host cell DAMP molecules´ functions.
format publishedVersion
author Cribb, Pamela
Perdomo, Virginia Gabriela
Alonso, Victoria Lucía
Manarin, Romina
Barrios-Payán, Jorge
Marquina-Castillo, Brenda
Tavernelli, Luis
Hernández-Pando, Rogelio
author_facet Cribb, Pamela
Perdomo, Virginia Gabriela
Alonso, Victoria Lucía
Manarin, Romina
Barrios-Payán, Jorge
Marquina-Castillo, Brenda
Tavernelli, Luis
Hernández-Pando, Rogelio
author_sort Cribb, Pamela
title Trypanosoma cruzi High Mobility Group B (TcHMGB) can act as an inflammatory mediator on mammalian cells
title_short Trypanosoma cruzi High Mobility Group B (TcHMGB) can act as an inflammatory mediator on mammalian cells
title_full Trypanosoma cruzi High Mobility Group B (TcHMGB) can act as an inflammatory mediator on mammalian cells
title_fullStr Trypanosoma cruzi High Mobility Group B (TcHMGB) can act as an inflammatory mediator on mammalian cells
title_full_unstemmed Trypanosoma cruzi High Mobility Group B (TcHMGB) can act as an inflammatory mediator on mammalian cells
title_sort trypanosoma cruzi high mobility group b (tchmgb) can act as an inflammatory mediator on mammalian cells
publisher Public Library of Science (PLOS)
publishDate 2021
url http://hdl.handle.net/2133/20196
http://hdl.handle.net/2133/20196
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