Sterol metabolism in the filasterean Capsaspora owczarzaki has features that resemble both fungi and animals

Sterols are essential for several physiological processes in most eukaryotes. Sterols regulate membrane homeostasis and participate in different signalling pathways not only as precursors of steroid hormones and vitamins, but also through its role in the formation of lipid rafts. Two major types...

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Autores principales: Najle, Sebastián R., Molina, María Celeste, Ruiz-Trillo, Iñaki, Uttaro, Antonio Domingo
Formato: publishedVersion
Lenguaje:Inglés
Publicado: The Royal Society 2021
Materias:
Capsaspora
Sterol Metabolism
Transcriptional Regulation
Opisthokonts
Cholesterol
Ergosterol
Acceso en línea:http://hdl.handle.net/2133/20171
http://hdl.handle.net/2133/20171
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-20171
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Capsaspora
Sterol Metabolism
Transcriptional Regulation
Opisthokonts
Cholesterol
Ergosterol
spellingShingle Capsaspora
Sterol Metabolism
Transcriptional Regulation
Opisthokonts
Cholesterol
Ergosterol
Najle, Sebastián R.
Molina, María Celeste
Ruiz-Trillo, Iñaki
Uttaro, Antonio Domingo
Sterol metabolism in the filasterean Capsaspora owczarzaki has features that resemble both fungi and animals
topic_facet Capsaspora
Sterol Metabolism
Transcriptional Regulation
Opisthokonts
Cholesterol
Ergosterol
description Sterols are essential for several physiological processes in most eukaryotes. Sterols regulate membrane homeostasis and participate in different signalling pathways not only as precursors of steroid hormones and vitamins, but also through its role in the formation of lipid rafts. Two major types of sterols, cholesterol and ergosterol, have been described so far in the opisthokonts, the clade that comprise animals, fungi and their unicellular relatives. Choles terol predominates in derived bilaterians, whereas ergosterol is what generally defines fungi. We here characterize, by a combination of bioinformatic and bio chemical analyses, the sterol metabolism in the filasterean Capsaspora owczarzaki, a close unicellular relative of animals that is becoming a model organism. We found that C. owczarzaki sterol metabolism combines enzymatic activities that are usually considered either characteristic of fungi or exclusive to metazoans. Moreover, we observe a differential transcriptional regulation of this metabolism across its life cycle. Thus, C. owczarzaki alternates between synthesizing 7-dehydrocholesterol de novo, which happens at the cystic stage, and the partial conversion—via a novel pathway—of incorporated cholesterol into ergosterol, the characteristic fungal sterol, in the filopodial and aggregative stages.
format publishedVersion
publishedVersion
author Najle, Sebastián R.
Molina, María Celeste
Ruiz-Trillo, Iñaki
Uttaro, Antonio Domingo
author_facet Najle, Sebastián R.
Molina, María Celeste
Ruiz-Trillo, Iñaki
Uttaro, Antonio Domingo
author_sort Najle, Sebastián R.
title Sterol metabolism in the filasterean Capsaspora owczarzaki has features that resemble both fungi and animals
title_short Sterol metabolism in the filasterean Capsaspora owczarzaki has features that resemble both fungi and animals
title_full Sterol metabolism in the filasterean Capsaspora owczarzaki has features that resemble both fungi and animals
title_fullStr Sterol metabolism in the filasterean Capsaspora owczarzaki has features that resemble both fungi and animals
title_full_unstemmed Sterol metabolism in the filasterean Capsaspora owczarzaki has features that resemble both fungi and animals
title_sort sterol metabolism in the filasterean capsaspora owczarzaki has features that resemble both fungi and animals
publisher The Royal Society
publishDate 2021
url http://hdl.handle.net/2133/20171
http://hdl.handle.net/2133/20171
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AT molinamariaceleste sterolmetabolisminthefilastereancapsasporaowczarzakihasfeaturesthatresemblebothfungiandanimals
AT ruiztrilloinaki sterolmetabolisminthefilastereancapsasporaowczarzakihasfeaturesthatresemblebothfungiandanimals
AT uttaroantoniodomingo sterolmetabolisminthefilastereancapsasporaowczarzakihasfeaturesthatresemblebothfungiandanimals
bdutipo_str Repositorios
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