Microbial flora, probiotics, Bacillus subtilis and the search for a long and healthy human longevity

Probiotics are live microorganisms that have beneficial effects on host health, including extended lifespan, when they are administered or present in adequate quantities. However, the mechanisms by which probiotics stimulate host longevity remain unclear and very poorly understood. In a re...

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Detalles Bibliográficos
Autores principales: Rodríguez Ayala, Facundo, Bauman, Carlos, Cogliati, Sebastián, Leñini, Cecilia, Bartolini, Marco, Grau, Roberto Ricardo
Formato: publishedVersion
Lenguaje:Inglés
Publicado: Shared Science Publishers 2021
Materias:
Bacillus subtilis
Probiotics
Biofilms
Healthy Longevity
Diet Therapy
Insulin Signaling
Acceso en línea:http://hdl.handle.net/2133/20128
http://hdl.handle.net/2133/20128
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-20128
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Bacillus subtilis
Probiotics
Biofilms
Healthy Longevity
Diet Therapy
Insulin Signaling
spellingShingle Bacillus subtilis
Probiotics
Biofilms
Healthy Longevity
Diet Therapy
Insulin Signaling
Rodríguez Ayala, Facundo
Bauman, Carlos
Cogliati, Sebastián
Leñini, Cecilia
Bartolini, Marco
Grau, Roberto Ricardo
Microbial flora, probiotics, Bacillus subtilis and the search for a long and healthy human longevity
topic_facet Bacillus subtilis
Probiotics
Biofilms
Healthy Longevity
Diet Therapy
Insulin Signaling
description Probiotics are live microorganisms that have beneficial effects on host health, including extended lifespan, when they are administered or present in adequate quantities. However, the mechanisms by which probiotics stimulate host longevity remain unclear and very poorly understood. In a recent study (Nat. Commun. 8, 14332 (2017) doi: 10.1038/ncomms14332), we used the spore-forming pro biotic bacterium Bacillus subtilis and the model organism Caenorhabditis elegans to study the mechanism by which a probiotic bacterium affects host longevity. We found that biofilm-proficient B. subtilis colonized the C. elegans gut and extended the worm lifespan significantly longer than did biofilm-deficient isogenic strains. In addition to biofilm proficiency, the quorum-sensing pentapeptide CSF and nitric oxide (NO) represent the entire B. subtilis rep ertoire responsible for the extended longevity of C. ele gans. B. subtilis grown under biofilm-supporting condi tions synthesized higher levels of NO and CSF than under planktonic growth conditions, emphasizing the key role of the biofilm in slowing host aging. Significantly, the pro longevity effect of B. subtilis was primarily due to a downregulation of the insulin-like signaling system that precisely is a key partaker in the healthy longevity of hu man centenarians. These findings open the possibility to test if the regular consumption of B. subtilis incorporated in foods and beverages could significantly extend human life expectancy and contribute to stop the development of age-related diseases.
format publishedVersion
author Rodríguez Ayala, Facundo
Bauman, Carlos
Cogliati, Sebastián
Leñini, Cecilia
Bartolini, Marco
Grau, Roberto Ricardo
author_facet Rodríguez Ayala, Facundo
Bauman, Carlos
Cogliati, Sebastián
Leñini, Cecilia
Bartolini, Marco
Grau, Roberto Ricardo
author_sort Rodríguez Ayala, Facundo
title Microbial flora, probiotics, Bacillus subtilis and the search for a long and healthy human longevity
title_short Microbial flora, probiotics, Bacillus subtilis and the search for a long and healthy human longevity
title_full Microbial flora, probiotics, Bacillus subtilis and the search for a long and healthy human longevity
title_fullStr Microbial flora, probiotics, Bacillus subtilis and the search for a long and healthy human longevity
title_full_unstemmed Microbial flora, probiotics, Bacillus subtilis and the search for a long and healthy human longevity
title_sort microbial flora, probiotics, bacillus subtilis and the search for a long and healthy human longevity
publisher Shared Science Publishers
publishDate 2021
url http://hdl.handle.net/2133/20128
http://hdl.handle.net/2133/20128
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