Sexual dimorphism of adipose and hepatic aquaglyceroporins in health and metabolic disorders

Gender differences in the relative risk of developing metabolic complications, such as insulin resistance or non-alcoholic fatty liver disease (NAFLD), have been reported. The deregulation of glycerol metabolism partly contributes to the onset of these metabolic diseases, since glycerol constitut...

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Autores principales: Rodríguez, Amaia, Marinelli, Raúl A., Tesse, Angela, Frühbeck, Gema, Calamita, Giuseppe
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: Frontiers Media 2021
Materias:
Glycerol
Metabolism
Aquaglyceroporins
Obesity
Insulin Resistance
Fatty Liver Disease (NAFLD)
Gender Dimorphism
Acceso en línea:http://hdl.handle.net/2133/19956
http://hdl.handle.net/2133/19956
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-19956
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Glycerol
Metabolism
Aquaglyceroporins
Obesity
Insulin Resistance
Fatty Liver Disease (NAFLD)
Gender Dimorphism
spellingShingle Glycerol
Metabolism
Aquaglyceroporins
Obesity
Insulin Resistance
Fatty Liver Disease (NAFLD)
Gender Dimorphism
Rodríguez, Amaia
Marinelli, Raúl A.
Tesse, Angela
Frühbeck, Gema
Calamita, Giuseppe
Sexual dimorphism of adipose and hepatic aquaglyceroporins in health and metabolic disorders
topic_facet Glycerol
Metabolism
Aquaglyceroporins
Obesity
Insulin Resistance
Fatty Liver Disease (NAFLD)
Gender Dimorphism
description Gender differences in the relative risk of developing metabolic complications, such as insulin resistance or non-alcoholic fatty liver disease (NAFLD), have been reported. The deregulation of glycerol metabolism partly contributes to the onset of these metabolic diseases, since glycerol constitutes a key substrate for the synthesis of triacylglycerols (TAGs) as well as for hepatic gluconeogenesis. The present mini-review covers the sexrelated differences in glycerol metabolism and aquaglyceroporins (AQPs) and its impact in the control of adipose and hepatic fat accumulation as well as in whole-body glucose homeostasis. Plasma glycerol concentrations are increased in women compared to men probably due to the higher lipolytic rate and larger AQP7 amounts in visceral fat as well as the well-known sexual dimorphism in fat mass with women showing higher adiposity. AQP9 represents the primary route for glycerol uptake in hepatocytes, where glycerol is converted by the glycerol-kinase enzyme into glycerol-3-phosphate, a key substrate for de novo synthesis of glucose and TAG. In spite of showing similar hepatic AQP9 protein, women exhibit lower hepatocyte glycerol permeability than men, which might contribute to their lower prevalence of insulin resistance and NAFLD.
format article
artículo
publishedVersion
author Rodríguez, Amaia
Marinelli, Raúl A.
Tesse, Angela
Frühbeck, Gema
Calamita, Giuseppe
author_facet Rodríguez, Amaia
Marinelli, Raúl A.
Tesse, Angela
Frühbeck, Gema
Calamita, Giuseppe
author_sort Rodríguez, Amaia
title Sexual dimorphism of adipose and hepatic aquaglyceroporins in health and metabolic disorders
title_short Sexual dimorphism of adipose and hepatic aquaglyceroporins in health and metabolic disorders
title_full Sexual dimorphism of adipose and hepatic aquaglyceroporins in health and metabolic disorders
title_fullStr Sexual dimorphism of adipose and hepatic aquaglyceroporins in health and metabolic disorders
title_full_unstemmed Sexual dimorphism of adipose and hepatic aquaglyceroporins in health and metabolic disorders
title_sort sexual dimorphism of adipose and hepatic aquaglyceroporins in health and metabolic disorders
publisher Frontiers Media
publishDate 2021
url http://hdl.handle.net/2133/19956
http://hdl.handle.net/2133/19956
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bdutipo_str Repositorios
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