In vitro alteration on erythrocytes mechanical properties by propofol, remifentanil and vecuronium

Several studies report flow disturbance and microcirculation disorders upon anesthesia treatment. These alterations are often related to blood rheology changes. In this work, it was attempted to make a detailed description of the alterations in erythrocyte mechanical properties by the action of prop...

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Detalles Bibliográficos
Autores principales:	Alet, Analía I., Batista da Silva, Marcus V., Castellini, Horacio V., Alet, Nicolás A., Riquelme, Bibiana Doris
Formato:	article artículo publishedVersion
Lenguaje:	Inglés
Publicado:	Elsevier 2021
Materias:	Propofol Remifentanil Erythrocyte viscoelasticity Vecuronium Hemorheology
Acceso en línea:	http://hdl.handle.net/2133/19671 http://hdl.handle.net/2133/19671
Aporte de:	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario

id	I15-R121-2133-19671
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institution	Universidad Nacional de Rosario
institution_str	I-15
repository_str	R-121
collection	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language	Inglés
orig_language_str_mv	eng
topic	Propofol Remifentanil Erythrocyte viscoelasticity Vecuronium Hemorheology
spellingShingle	Propofol Remifentanil Erythrocyte viscoelasticity Vecuronium Hemorheology Alet, Analía I. Batista da Silva, Marcus V. Castellini, Horacio V. Alet, Nicolás A. Riquelme, Bibiana Doris In vitro alteration on erythrocytes mechanical properties by propofol, remifentanil and vecuronium
topic_facet	Propofol Remifentanil Erythrocyte viscoelasticity Vecuronium Hemorheology
description	Several studies report flow disturbance and microcirculation disorders upon anesthesia treatment. These alterations are often related to blood rheology changes. In this work, it was attempted to make a detailed description of the alterations in erythrocyte mechanical properties by the action of propofol, remifentanil, and vecuronium. For this, an in vitro study was performed on red blood cell samples from healthy donors incubated with solutions of propofol (4 μg/mL whole blood), remifentanil (10 ng/mL plasma), and vecuronium (0.15 μg/mL plasma). Erythrocyte viscoelastic parameters were determined by octuplicate using a Reómetro Eritrocitario. Also, a Wilcoxon signed rank-test with Yates correction for continuity was performed to analyze the overall alteration in the mechanical properties of erythrocytes. Statistical analysis showed that the three studied anesthetics changed the erythrocyte mechanical properties at different parts of the membrane. These results would imply an interaction of these anesthetics with the erythrocyte membrane. Finally, this could conduce to alterations in microcirculation.
format	article artículo publishedVersion
author	Alet, Analía I. Batista da Silva, Marcus V. Castellini, Horacio V. Alet, Nicolás A. Riquelme, Bibiana Doris
author_facet	Alet, Analía I. Batista da Silva, Marcus V. Castellini, Horacio V. Alet, Nicolás A. Riquelme, Bibiana Doris
author_sort	Alet, Analía I.
title	In vitro alteration on erythrocytes mechanical properties by propofol, remifentanil and vecuronium
title_short	In vitro alteration on erythrocytes mechanical properties by propofol, remifentanil and vecuronium
title_full	In vitro alteration on erythrocytes mechanical properties by propofol, remifentanil and vecuronium
title_fullStr	In vitro alteration on erythrocytes mechanical properties by propofol, remifentanil and vecuronium
title_full_unstemmed	In vitro alteration on erythrocytes mechanical properties by propofol, remifentanil and vecuronium
title_sort	in vitro alteration on erythrocytes mechanical properties by propofol, remifentanil and vecuronium
publisher	Elsevier
publishDate	2021
url	http://hdl.handle.net/2133/19671 http://hdl.handle.net/2133/19671
work_keys_str_mv	AT aletanaliai invitroalterationonerythrocytesmechanicalpropertiesbypropofolremifentanilandvecuronium AT batistadasilvamarcusv invitroalterationonerythrocytesmechanicalpropertiesbypropofolremifentanilandvecuronium AT castellinihoraciov invitroalterationonerythrocytesmechanicalpropertiesbypropofolremifentanilandvecuronium AT aletnicolasa invitroalterationonerythrocytesmechanicalpropertiesbypropofolremifentanilandvecuronium AT riquelmebibianadoris invitroalterationonerythrocytesmechanicalpropertiesbypropofolremifentanilandvecuronium
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In vitro alteration on erythrocytes mechanical properties by propofol, remifentanil and vecuronium

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