Antifungal activity of pyranonaphthoquinones obtained from Cipura paludosa bulbs
Previous studies with the bulbs of Cipura paludosa (Iridaceae) showed the presence of pyranonaphthoquinones, including eleutherine, isoeleutherine and eleutherol. The aim of this study was to evaluate the antifungal properties of these compounds. The activity was tested against the clinically relev...
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Autores principales: | , , , , , |
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Formato: | article artículo publishedVersion |
Lenguaje: | Inglés |
Publicado: |
SAGE
2020
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Materias: | |
Acceso en línea: | http://hdl.handle.net/2133/19533 http://hdl.handle.net/2133/19533 |
Aporte de: |
id |
I15-R121-2133-19533 |
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record_format |
dspace |
institution |
Universidad Nacional de Rosario |
institution_str |
I-15 |
repository_str |
R-121 |
collection |
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) |
language |
Inglés |
orig_language_str_mv |
eng |
topic |
Cipura paludosa Antifungal Activity Pyranonaphthoquinones |
spellingShingle |
Cipura paludosa Antifungal Activity Pyranonaphthoquinones Campos, Adriana Rodrigues Souza, Greice Maria Delle Monache, Franco Butassi, Estefanía Zacchino, Susana Cechinel Filho, Valdir Antifungal activity of pyranonaphthoquinones obtained from Cipura paludosa bulbs |
topic_facet |
Cipura paludosa Antifungal Activity Pyranonaphthoquinones |
description |
Previous studies with the bulbs of Cipura paludosa (Iridaceae) showed the presence of pyranonaphthoquinones, including eleutherine, isoeleutherine and
eleutherol. The aim of this study was to evaluate the antifungal properties of these compounds. The activity was tested against the clinically relevant yeasts
Candida albicans, C. tropicalis, Saccharomyces cerevisiae and Cryptococcus neoformans with the microbroth dilution method, following the guidelines of
CLSI. Eleutherine, isoeleutherine and eleutherol all presented significant antifungal activity, especially the first two, the major components, with MIC values
between 7.8 and 250 µg/mL. In conclusion, these results demonstrate that C. paludosa bulbs produce active principles with relevant antifungal potential,
contributing, at least in part, to the antimicrobial effect evidenced for this plant and justifying its popular use against infections. |
format |
article artículo publishedVersion |
author |
Campos, Adriana Rodrigues Souza, Greice Maria Delle Monache, Franco Butassi, Estefanía Zacchino, Susana Cechinel Filho, Valdir |
author_facet |
Campos, Adriana Rodrigues Souza, Greice Maria Delle Monache, Franco Butassi, Estefanía Zacchino, Susana Cechinel Filho, Valdir |
author_sort |
Campos, Adriana |
title |
Antifungal activity of pyranonaphthoquinones obtained from Cipura paludosa bulbs |
title_short |
Antifungal activity of pyranonaphthoquinones obtained from Cipura paludosa bulbs |
title_full |
Antifungal activity of pyranonaphthoquinones obtained from Cipura paludosa bulbs |
title_fullStr |
Antifungal activity of pyranonaphthoquinones obtained from Cipura paludosa bulbs |
title_full_unstemmed |
Antifungal activity of pyranonaphthoquinones obtained from Cipura paludosa bulbs |
title_sort |
antifungal activity of pyranonaphthoquinones obtained from cipura paludosa bulbs |
publisher |
SAGE |
publishDate |
2020 |
url |
http://hdl.handle.net/2133/19533 http://hdl.handle.net/2133/19533 |
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bdutipo_str |
Repositorios |
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