Antifungal activity of pyranonaphthoquinones obtained from Cipura paludosa bulbs

Previous studies with the bulbs of Cipura paludosa (Iridaceae) showed the presence of pyranonaphthoquinones, including eleutherine, isoeleutherine and eleutherol. The aim of this study was to evaluate the antifungal properties of these compounds. The activity was tested against the clinically relev...

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Autores principales: Campos, Adriana, Rodrigues Souza, Greice Maria, Delle Monache, Franco, Butassi, Estefanía, Zacchino, Susana, Cechinel Filho, Valdir
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: SAGE 2020
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Acceso en línea:http://hdl.handle.net/2133/19533
http://hdl.handle.net/2133/19533
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id I15-R121-2133-19533
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Cipura paludosa
Antifungal Activity
Pyranonaphthoquinones
spellingShingle Cipura paludosa
Antifungal Activity
Pyranonaphthoquinones
Campos, Adriana
Rodrigues Souza, Greice Maria
Delle Monache, Franco
Butassi, Estefanía
Zacchino, Susana
Cechinel Filho, Valdir
Antifungal activity of pyranonaphthoquinones obtained from Cipura paludosa bulbs
topic_facet Cipura paludosa
Antifungal Activity
Pyranonaphthoquinones
description Previous studies with the bulbs of Cipura paludosa (Iridaceae) showed the presence of pyranonaphthoquinones, including eleutherine, isoeleutherine and eleutherol. The aim of this study was to evaluate the antifungal properties of these compounds. The activity was tested against the clinically relevant yeasts Candida albicans, C. tropicalis, Saccharomyces cerevisiae and Cryptococcus neoformans with the microbroth dilution method, following the guidelines of CLSI. Eleutherine, isoeleutherine and eleutherol all presented significant antifungal activity, especially the first two, the major components, with MIC values between 7.8 and 250 µg/mL. In conclusion, these results demonstrate that C. paludosa bulbs produce active principles with relevant antifungal potential, contributing, at least in part, to the antimicrobial effect evidenced for this plant and justifying its popular use against infections.
format article
artículo
publishedVersion
author Campos, Adriana
Rodrigues Souza, Greice Maria
Delle Monache, Franco
Butassi, Estefanía
Zacchino, Susana
Cechinel Filho, Valdir
author_facet Campos, Adriana
Rodrigues Souza, Greice Maria
Delle Monache, Franco
Butassi, Estefanía
Zacchino, Susana
Cechinel Filho, Valdir
author_sort Campos, Adriana
title Antifungal activity of pyranonaphthoquinones obtained from Cipura paludosa bulbs
title_short Antifungal activity of pyranonaphthoquinones obtained from Cipura paludosa bulbs
title_full Antifungal activity of pyranonaphthoquinones obtained from Cipura paludosa bulbs
title_fullStr Antifungal activity of pyranonaphthoquinones obtained from Cipura paludosa bulbs
title_full_unstemmed Antifungal activity of pyranonaphthoquinones obtained from Cipura paludosa bulbs
title_sort antifungal activity of pyranonaphthoquinones obtained from cipura paludosa bulbs
publisher SAGE
publishDate 2020
url http://hdl.handle.net/2133/19533
http://hdl.handle.net/2133/19533
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