A new n-methoxypyridone from the co-cultivation of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062

A new N-methoxypyridone analog (1), together with four known compounds, was isolated from the co-culture of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062. The structure of the new compound was elucidated as 11S-hydroxy-1-methoxyfusaricide (1) by extensive spec...

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Autores principales: Li, Chun-shun, Sarotti, Ariel Marcelo, Yang, Baojun, Turkson, James, Cao, Shugeng
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: MDPI 2020
Materias:
Endophytic Fungi
Coculture Techniques
Pyridones
Tetramic Acid
Hawaii
Acceso en línea:http://hdl.handle.net/2133/19532
http://hdl.handle.net/2133/19532
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-19532
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Endophytic Fungi
Coculture Techniques
Pyridones
Tetramic Acid
Hawaii
spellingShingle Endophytic Fungi
Coculture Techniques
Pyridones
Tetramic Acid
Hawaii
Li, Chun-shun
Sarotti, Ariel Marcelo
Yang, Baojun
Turkson, James
Cao, Shugeng
A new n-methoxypyridone from the co-cultivation of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062
topic_facet Endophytic Fungi
Coculture Techniques
Pyridones
Tetramic Acid
Hawaii
description A new N-methoxypyridone analog (1), together with four known compounds, was isolated from the co-culture of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062. The structure of the new compound was elucidated as 11S-hydroxy-1-methoxyfusaricide (1) by extensive spectroscopic analysis and comparison with the literature. The absolute configuration of 1 was determined by comparison with the experimental and calculated ECD spectra. The absolute configuration of compound 3 was investigated and renamed as (+)-epipyridone by comparison of the optical rotation and CD spectrum with those of 1. The other known compounds were identified as epicoccarine B (2), D8646-2-6 (4), and iso-D8646-2-6 (5). Compounds 4 and 5 showed modest inhibitory activity towards pathogenic fungi. Epicoccarine B (2) inhibited A2780 and TK-10 with an IC50 value of 22 µM.
format article
artículo
publishedVersion
author Li, Chun-shun
Sarotti, Ariel Marcelo
Yang, Baojun
Turkson, James
Cao, Shugeng
author_facet Li, Chun-shun
Sarotti, Ariel Marcelo
Yang, Baojun
Turkson, James
Cao, Shugeng
author_sort Li, Chun-shun
title A new n-methoxypyridone from the co-cultivation of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062
title_short A new n-methoxypyridone from the co-cultivation of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062
title_full A new n-methoxypyridone from the co-cultivation of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062
title_fullStr A new n-methoxypyridone from the co-cultivation of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062
title_full_unstemmed A new n-methoxypyridone from the co-cultivation of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062
title_sort new n-methoxypyridone from the co-cultivation of hawaiian endophytic fungi camporesia sambuci ft1061 and epicoccum sorghinum ft1062
publisher MDPI
publishDate 2020
url http://hdl.handle.net/2133/19532
http://hdl.handle.net/2133/19532
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