Hybrid molecules containing a 7-chloro-4-aminoquinoline nucleus and a substituted 2-Pyrazoline with antiproliferative and antifungal activity

Twenty-four new hybrid analogues (15–38) containing 7-chloro-4-aminoquinoline and 2-pyrazoline N-heterocyclic fragments were synthesized. Twelve of the new compounds were evaluated against 58 human cancer cell lines by the U.S. National Cancer Institute (NCI). Compounds 25, 30, 31, 36, and 37 sho...

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Autores principales: Montoya, Alba, Quiroga, Jairo, Abonia, Rodrigo, Derita, Marcos, Sortino, Maximiliano, Ornelas, Alfredo, Zacchino, Susana, Insuasty, Braulio
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: MDPI 2020
Materias:
Cyclocondensation Reaction
Chalcones
N-aryl-2-pyrazolines
Antifungal Activity
Antiproliferative Activity
Acceso en línea:http://hdl.handle.net/2133/19513
http://hdl.handle.net/2133/19513
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-19513
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Cyclocondensation Reaction
Chalcones
N-aryl-2-pyrazolines
Antifungal Activity
Antiproliferative Activity
spellingShingle Cyclocondensation Reaction
Chalcones
N-aryl-2-pyrazolines
Antifungal Activity
Antiproliferative Activity
Montoya, Alba
Quiroga, Jairo
Abonia, Rodrigo
Derita, Marcos
Sortino, Maximiliano
Ornelas, Alfredo
Zacchino, Susana
Insuasty, Braulio
Hybrid molecules containing a 7-chloro-4-aminoquinoline nucleus and a substituted 2-Pyrazoline with antiproliferative and antifungal activity
topic_facet Cyclocondensation Reaction
Chalcones
N-aryl-2-pyrazolines
Antifungal Activity
Antiproliferative Activity
description Twenty-four new hybrid analogues (15–38) containing 7-chloro-4-aminoquinoline and 2-pyrazoline N-heterocyclic fragments were synthesized. Twelve of the new compounds were evaluated against 58 human cancer cell lines by the U.S. National Cancer Institute (NCI). Compounds 25, 30, 31, 36, and 37 showed significant cytostatic activity, with the most outstanding GI50 values ranging from 0.05 to 0.95 µM. The hybrid compounds (15–38) were also evaluated for antifungal activity against Candida albicans and Cryptococcus neoformans. From the obtained results some structure–activity relationships were outlined.
format article
artículo
publishedVersion
author Montoya, Alba
Quiroga, Jairo
Abonia, Rodrigo
Derita, Marcos
Sortino, Maximiliano
Ornelas, Alfredo
Zacchino, Susana
Insuasty, Braulio
author_facet Montoya, Alba
Quiroga, Jairo
Abonia, Rodrigo
Derita, Marcos
Sortino, Maximiliano
Ornelas, Alfredo
Zacchino, Susana
Insuasty, Braulio
author_sort Montoya, Alba
title Hybrid molecules containing a 7-chloro-4-aminoquinoline nucleus and a substituted 2-Pyrazoline with antiproliferative and antifungal activity
title_short Hybrid molecules containing a 7-chloro-4-aminoquinoline nucleus and a substituted 2-Pyrazoline with antiproliferative and antifungal activity
title_full Hybrid molecules containing a 7-chloro-4-aminoquinoline nucleus and a substituted 2-Pyrazoline with antiproliferative and antifungal activity
title_fullStr Hybrid molecules containing a 7-chloro-4-aminoquinoline nucleus and a substituted 2-Pyrazoline with antiproliferative and antifungal activity
title_full_unstemmed Hybrid molecules containing a 7-chloro-4-aminoquinoline nucleus and a substituted 2-Pyrazoline with antiproliferative and antifungal activity
title_sort hybrid molecules containing a 7-chloro-4-aminoquinoline nucleus and a substituted 2-pyrazoline with antiproliferative and antifungal activity
publisher MDPI
publishDate 2020
url http://hdl.handle.net/2133/19513
http://hdl.handle.net/2133/19513
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