Molecular diversity by olefin cross-metathesis on solid support. Generation of libraries of biologically promising β-lactam derivatives
The application of the reagent-based diversification strategy for generation of libraries of biologically promising β-lactam derivatives is described. Key features are the versatility of the linker used and the cross-metathesis functionalization at the cleavage step. From an immobilized primary l...
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| Autores principales: | , , |
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| Formato: | article artículo publishedVersion |
| Lenguaje: | Inglés |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/2133/19505 http://hdl.handle.net/2133/19505 |
| Aporte de: |
| Sumario: | The application of the reagent-based diversification strategy for generation of libraries
of biologically promising β-lactam derivatives is described. Key features are the versatility of the
linker used and the cross-metathesis functionalization at the cleavage step. From an immobilized
primary library, diversity was expanded by applying different cleavage conditions, leading to a series
of cholesterol absorption inhibitor analogues together with interesting hybrid compounds through
incorporation of a chalcone moiety. |
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