Molecular diversity by olefin cross-metathesis on solid support. Generation of libraries of biologically promising β-lactam derivatives

The application of the reagent-based diversification strategy for generation of libraries of biologically promising β-lactam derivatives is described. Key features are the versatility of the linker used and the cross-metathesis functionalization at the cleavage step. From an immobilized primary l...

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Detalles Bibliográficos
Autores principales:	Méndez, Luciana, Poeylaut-Palena, Andrés A., Mata, Ernesto Gabino
Formato:	article artículo publishedVersion
Lenguaje:	Inglés
Publicado:	MDPI 2020
Materias:	Diversity-oriented Synthesis Solid-Phase Organic Synthesis beta-Lactam Derivatives Alkenes Metathesis Cholesterol Absorption Inhibitors
Acceso en línea:	http://hdl.handle.net/2133/19505 http://hdl.handle.net/2133/19505
Aporte de:	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario

id	I15-R121-2133-19505
record_format	dspace
institution	Universidad Nacional de Rosario
institution_str	I-15
repository_str	R-121
collection	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language	Inglés
orig_language_str_mv	eng
topic	Diversity-oriented Synthesis Solid-Phase Organic Synthesis beta-Lactam Derivatives Alkenes Metathesis Cholesterol Absorption Inhibitors
spellingShingle	Diversity-oriented Synthesis Solid-Phase Organic Synthesis beta-Lactam Derivatives Alkenes Metathesis Cholesterol Absorption Inhibitors Méndez, Luciana Poeylaut-Palena, Andrés A. Mata, Ernesto Gabino Molecular diversity by olefin cross-metathesis on solid support. Generation of libraries of biologically promising β-lactam derivatives
topic_facet	Diversity-oriented Synthesis Solid-Phase Organic Synthesis beta-Lactam Derivatives Alkenes Metathesis Cholesterol Absorption Inhibitors
description	The application of the reagent-based diversification strategy for generation of libraries of biologically promising β-lactam derivatives is described. Key features are the versatility of the linker used and the cross-metathesis functionalization at the cleavage step. From an immobilized primary library, diversity was expanded by applying different cleavage conditions, leading to a series of cholesterol absorption inhibitor analogues together with interesting hybrid compounds through incorporation of a chalcone moiety.
format	article artículo publishedVersion
author	Méndez, Luciana Poeylaut-Palena, Andrés A. Mata, Ernesto Gabino
author_facet	Méndez, Luciana Poeylaut-Palena, Andrés A. Mata, Ernesto Gabino
author_sort	Méndez, Luciana
title	Molecular diversity by olefin cross-metathesis on solid support. Generation of libraries of biologically promising β-lactam derivatives
title_short	Molecular diversity by olefin cross-metathesis on solid support. Generation of libraries of biologically promising β-lactam derivatives
title_full	Molecular diversity by olefin cross-metathesis on solid support. Generation of libraries of biologically promising β-lactam derivatives
title_fullStr	Molecular diversity by olefin cross-metathesis on solid support. Generation of libraries of biologically promising β-lactam derivatives
title_full_unstemmed	Molecular diversity by olefin cross-metathesis on solid support. Generation of libraries of biologically promising β-lactam derivatives
title_sort	molecular diversity by olefin cross-metathesis on solid support. generation of libraries of biologically promising β-lactam derivatives
publisher	MDPI
publishDate	2020
url	http://hdl.handle.net/2133/19505 http://hdl.handle.net/2133/19505
work_keys_str_mv	AT mendezluciana moleculardiversitybyolefincrossmetathesisonsolidsupportgenerationoflibrariesofbiologicallypromisingblactamderivatives AT poeylautpalenaandresa moleculardiversitybyolefincrossmetathesisonsolidsupportgenerationoflibrariesofbiologicallypromisingblactamderivatives AT mataernestogabino moleculardiversitybyolefincrossmetathesisonsolidsupportgenerationoflibrariesofbiologicallypromisingblactamderivatives
bdutipo_str	Repositorios
_version_	1764820410905395200

Molecular diversity by olefin cross-metathesis on solid support. Generation of libraries of biologically promising β-lactam derivatives

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