An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431

A new polyketide containing the benzoisoquinoline-9-one moiety, peyronetide A (1), and three other new derivatives peyronetides B–D (2–4), as well as one known compound (5) were purified from the cultured broth of the endophytic fungus Peyronellaea sp. FT431, which was isolated from the Hawaiian...

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Autores principales:	Li, Chun-shun, Sarotti, Ariel Marcelo, Wu, Xiaohua, Yang, Baojun, Turkson, James, Chen, Yongfei, Liu, Qingsong, Cao, Shugeng
Formato:	article artículo publishedVersion
Lenguaje:	Inglés
Publicado:	MDPI 2020
Materias:	Endophytic Fungi Peyronellaea Benzoisoquinoline-9-one Antiproliferative Activity Hawaii
Acceso en línea:	http://hdl.handle.net/2133/19504 http://hdl.handle.net/2133/19504
Aporte de:	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario

id	I15-R121-2133-19504
record_format	dspace
institution	Universidad Nacional de Rosario
institution_str	I-15
repository_str	R-121
collection	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language	Inglés
orig_language_str_mv	eng
topic	Endophytic Fungi Peyronellaea Benzoisoquinoline-9-one Antiproliferative Activity Hawaii
spellingShingle	Endophytic Fungi Peyronellaea Benzoisoquinoline-9-one Antiproliferative Activity Hawaii Li, Chun-shun Sarotti, Ariel Marcelo Wu, Xiaohua Yang, Baojun Turkson, James Chen, Yongfei Liu, Qingsong Cao, Shugeng An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431
topic_facet	Endophytic Fungi Peyronellaea Benzoisoquinoline-9-one Antiproliferative Activity Hawaii
description	A new polyketide containing the benzoisoquinoline-9-one moiety, peyronetide A (1), and three other new derivatives peyronetides B–D (2–4), as well as one known compound (5) were purified from the cultured broth of the endophytic fungus Peyronellaea sp. FT431, which was isolated from the Hawaiian indigenous plant, Verbena sp. The structures of the new compounds were determined through the analysis of HRMS and NMR spectroscopic data. Compounds 1, 2, and 5 showed cytotoxic activities against TK-10 (human kidney adenocarcinoma cells), cisplatin sensitive A2780S (human ovarian carcinoma cells), and cisplatin resistant A2780CisR cell lines, with IC50 values between 6.7 to 29.2 µM.
format	article artículo publishedVersion
author	Li, Chun-shun Sarotti, Ariel Marcelo Wu, Xiaohua Yang, Baojun Turkson, James Chen, Yongfei Liu, Qingsong Cao, Shugeng
author_facet	Li, Chun-shun Sarotti, Ariel Marcelo Wu, Xiaohua Yang, Baojun Turkson, James Chen, Yongfei Liu, Qingsong Cao, Shugeng
author_sort	Li, Chun-shun
title	An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431
title_short	An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431
title_full	An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431
title_fullStr	An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431
title_full_unstemmed	An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431
title_sort	unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from hawaiian endophytic fungus peyronellaea sp. ft431
publisher	MDPI
publishDate	2020
url	http://hdl.handle.net/2133/19504 http://hdl.handle.net/2133/19504
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bdutipo_str	Repositorios
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An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431

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