Antimicrobial, anti-inflammatory and antioxidant activities of polyoxygenated chalcones

It was synthesized nine polyoxygenated chalcones with a potential and safe use as antioxidant, antimicrobial and anti-inflammatory therapies. Chalcones obtained by Claisen-Schmidt condensation were studied as antioxidant, inhibitors of human 5-lipoxygenase, antifungal, antibacterial and antibioti...

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Detalles Bibliográficos
Autores principales: Vásquez-Martínez, Yesseny A., Osorio, Mauricio E., San Martín, Diego A., Carvajal, Marcela A., Vergara, Alejandra P., Sanchez, Elizabeth, Raimondi, Marcela, Zacchino, Susana, Mascayano, Carolina, Torrent, Claudia, Cabezas, Francisco, Mejias, Sophia, Montoya, Margarita, Cortez-San Martín, Marcelo
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: Sociedade Brasileira de Química 2020
Materias:
Polyoxygenated Chalcones
Antioxidant Activity
Antifungal Activity
Antibacterial Activity
Lipoxygenase Inhibitors
Acceso en línea:http://hdl.handle.net/2133/19500
http://hdl.handle.net/2133/19500
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
Descripción
Sumario:It was synthesized nine polyoxygenated chalcones with a potential and safe use as antioxidant, antimicrobial and anti-inflammatory therapies. Chalcones obtained by Claisen-Schmidt condensation were studied as antioxidant, inhibitors of human 5-lipoxygenase, antifungal, antibacterial and antibiotic resistance modifiers. Two chalcones with catecholic moieties were able to strongly decrease the minimum inhibitory concentration (MIC) of methicillin against methicillin-resistant Staphylococcus aureus, increase the antiradical activity and significantly inhibit the human 5-lipoxygenase. Only one of these chalcones was active synergistically with methicillin. Chalcones with methoxyl substituents at different positions displayed the best activities against Cryptococcus neoformans. Only one chalcone showed good activity against the plant pathogenic bacteria Pseudomonas syringae whose half maximal inhibitory concentration (IC50) value (2.5 µg mL-1) was similar to that observed with the antibiotic streptomycin (2.9 µg mL-1). These simple chalcones have safe potential uses in antioxidant, antimicrobial and anti-inflammatory therapies.

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