Antimicrobial, anti-inflammatory and antioxidant activities of polyoxygenated chalcones

It was synthesized nine polyoxygenated chalcones with a potential and safe use as antioxidant, antimicrobial and anti-inflammatory therapies. Chalcones obtained by Claisen-Schmidt condensation were studied as antioxidant, inhibitors of human 5-lipoxygenase, antifungal, antibacterial and antibioti...

Descripción completa

Detalles Bibliográficos
Autores principales: Vásquez-Martínez, Yesseny A., Osorio, Mauricio E., San Martín, Diego A., Carvajal, Marcela A., Vergara, Alejandra P., Sanchez, Elizabeth, Raimondi, Marcela, Zacchino, Susana, Mascayano, Carolina, Torrent, Claudia, Cabezas, Francisco, Mejias, Sophia, Montoya, Margarita, Cortez-San Martín, Marcelo
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: Sociedade Brasileira de Química 2020
Materias:
Polyoxygenated Chalcones
Antioxidant Activity
Antifungal Activity
Antibacterial Activity
Lipoxygenase Inhibitors
Acceso en línea:http://hdl.handle.net/2133/19500
http://hdl.handle.net/2133/19500
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-19500
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Polyoxygenated Chalcones
Antioxidant Activity
Antifungal Activity
Antibacterial Activity
Lipoxygenase Inhibitors
spellingShingle Polyoxygenated Chalcones
Antioxidant Activity
Antifungal Activity
Antibacterial Activity
Lipoxygenase Inhibitors
Vásquez-Martínez, Yesseny A.
Osorio, Mauricio E.
San Martín, Diego A.
Carvajal, Marcela A.
Vergara, Alejandra P.
Sanchez, Elizabeth
Raimondi, Marcela
Zacchino, Susana
Mascayano, Carolina
Torrent, Claudia
Cabezas, Francisco
Mejias, Sophia
Montoya, Margarita
Cortez-San Martín, Marcelo
Antimicrobial, anti-inflammatory and antioxidant activities of polyoxygenated chalcones
topic_facet Polyoxygenated Chalcones
Antioxidant Activity
Antifungal Activity
Antibacterial Activity
Lipoxygenase Inhibitors
description It was synthesized nine polyoxygenated chalcones with a potential and safe use as antioxidant, antimicrobial and anti-inflammatory therapies. Chalcones obtained by Claisen-Schmidt condensation were studied as antioxidant, inhibitors of human 5-lipoxygenase, antifungal, antibacterial and antibiotic resistance modifiers. Two chalcones with catecholic moieties were able to strongly decrease the minimum inhibitory concentration (MIC) of methicillin against methicillin-resistant Staphylococcus aureus, increase the antiradical activity and significantly inhibit the human 5-lipoxygenase. Only one of these chalcones was active synergistically with methicillin. Chalcones with methoxyl substituents at different positions displayed the best activities against Cryptococcus neoformans. Only one chalcone showed good activity against the plant pathogenic bacteria Pseudomonas syringae whose half maximal inhibitory concentration (IC50) value (2.5 µg mL-1) was similar to that observed with the antibiotic streptomycin (2.9 µg mL-1). These simple chalcones have safe potential uses in antioxidant, antimicrobial and anti-inflammatory therapies.
format article
artículo
publishedVersion
author Vásquez-Martínez, Yesseny A.
Osorio, Mauricio E.
San Martín, Diego A.
Carvajal, Marcela A.
Vergara, Alejandra P.
Sanchez, Elizabeth
Raimondi, Marcela
Zacchino, Susana
Mascayano, Carolina
Torrent, Claudia
Cabezas, Francisco
Mejias, Sophia
Montoya, Margarita
Cortez-San Martín, Marcelo
author_facet Vásquez-Martínez, Yesseny A.
Osorio, Mauricio E.
San Martín, Diego A.
Carvajal, Marcela A.
Vergara, Alejandra P.
Sanchez, Elizabeth
Raimondi, Marcela
Zacchino, Susana
Mascayano, Carolina
Torrent, Claudia
Cabezas, Francisco
Mejias, Sophia
Montoya, Margarita
Cortez-San Martín, Marcelo
author_sort Vásquez-Martínez, Yesseny A.
title Antimicrobial, anti-inflammatory and antioxidant activities of polyoxygenated chalcones
title_short Antimicrobial, anti-inflammatory and antioxidant activities of polyoxygenated chalcones
title_full Antimicrobial, anti-inflammatory and antioxidant activities of polyoxygenated chalcones
title_fullStr Antimicrobial, anti-inflammatory and antioxidant activities of polyoxygenated chalcones
title_full_unstemmed Antimicrobial, anti-inflammatory and antioxidant activities of polyoxygenated chalcones
title_sort antimicrobial, anti-inflammatory and antioxidant activities of polyoxygenated chalcones
publisher Sociedade Brasileira de Química
publishDate 2020
url http://hdl.handle.net/2133/19500
http://hdl.handle.net/2133/19500
work_keys_str_mv AT vasquezmartinezyessenya antimicrobialantiinflammatoryandantioxidantactivitiesofpolyoxygenatedchalcones
AT osoriomauricioe antimicrobialantiinflammatoryandantioxidantactivitiesofpolyoxygenatedchalcones
AT sanmartindiegoa antimicrobialantiinflammatoryandantioxidantactivitiesofpolyoxygenatedchalcones
AT carvajalmarcelaa antimicrobialantiinflammatoryandantioxidantactivitiesofpolyoxygenatedchalcones
AT vergaraalejandrap antimicrobialantiinflammatoryandantioxidantactivitiesofpolyoxygenatedchalcones
AT sanchezelizabeth antimicrobialantiinflammatoryandantioxidantactivitiesofpolyoxygenatedchalcones
AT raimondimarcela antimicrobialantiinflammatoryandantioxidantactivitiesofpolyoxygenatedchalcones
AT zacchinosusana antimicrobialantiinflammatoryandantioxidantactivitiesofpolyoxygenatedchalcones
AT mascayanocarolina antimicrobialantiinflammatoryandantioxidantactivitiesofpolyoxygenatedchalcones
AT torrentclaudia antimicrobialantiinflammatoryandantioxidantactivitiesofpolyoxygenatedchalcones
AT cabezasfrancisco antimicrobialantiinflammatoryandantioxidantactivitiesofpolyoxygenatedchalcones
AT mejiassophia antimicrobialantiinflammatoryandantioxidantactivitiesofpolyoxygenatedchalcones
AT montoyamargarita antimicrobialantiinflammatoryandantioxidantactivitiesofpolyoxygenatedchalcones
AT cortezsanmartinmarcelo antimicrobialantiinflammatoryandantioxidantactivitiesofpolyoxygenatedchalcones
bdutipo_str Repositorios
_version_ 1764820410895958017

Ejemplares similares