Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models

Aim: According to the need for the development of new anticancer agents, we have synthetized novel bioactive compounds and aimed to determine their antitumor action. Materials & methods: We describe in vitro studies evaluating the effect of 35 novel chemical compounds on two triple negative muri...

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Autores principales:	Giolito, Maria Virginia, Camacho, Cristian M., Martinez-Amezaga, Maitena, Traficante, Carla Inés, Giordano, Rocío A., Cornier, Patricia G., Mata, Ernesto G., Delpiccolo, Carina M.L., Boggián, Dora G., Del Giúdice, Antonela, Mainetti, Leandro Ernesto, Scharovsky, Olga Graciela, Rozados, Viviana R., Rico, María José
Formato:	article artículo publishedVersion
Lenguaje:	Inglés
Publicado:	Future Science Group 2020
Materias:	Antitumor effect Chemical agents In vitro assays Triple negative mammary adenocarcinoma
Acceso en línea:	http://hdl.handle.net/2133/19381 http://hdl.handle.net/2133/19381
Aporte de:	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario

id	I15-R121-2133-19381
record_format	dspace
institution	Universidad Nacional de Rosario
institution_str	I-15
repository_str	R-121
collection	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language	Inglés
orig_language_str_mv	eng
topic	Antitumor effect Chemical agents In vitro assays Triple negative mammary adenocarcinoma
spellingShingle	Antitumor effect Chemical agents In vitro assays Triple negative mammary adenocarcinoma Giolito, Maria Virginia Camacho, Cristian M. Martinez-Amezaga, Maitena Traficante, Carla Inés Giordano, Rocío A. Cornier, Patricia G. Mata, Ernesto G. Delpiccolo, Carina M.L. Boggián, Dora G. Del Giúdice, Antonela Mainetti, Leandro Ernesto Scharovsky, Olga Graciela Rozados, Viviana R. Rico, María José Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models
topic_facet	Antitumor effect Chemical agents In vitro assays Triple negative mammary adenocarcinoma
description	Aim: According to the need for the development of new anticancer agents, we have synthetized novel bioactive compounds and aimed to determine their antitumor action. Materials & methods: We describe in vitro studies evaluating the effect of 35 novel chemical compounds on two triple negative murine mammary adenocarcinoma tumors. Results & conclusion: Three compounds were selected because of their high antitumor activity and their low toxicity to normal cells. Their effect on tumor cells apoptosis, clonogenicity and migratory capacity, were determined. We found that the selected compounds showed inhibition of viability and clonogenic capacity, and promotion of apoptosis. They also decreased the migratory capacity of tumor cells. The results obtained suggest the likelihood of their future use as antitumor and/or antimetastatic agents.
format	article artículo publishedVersion
author	Giolito, Maria Virginia Camacho, Cristian M. Martinez-Amezaga, Maitena Traficante, Carla Inés Giordano, Rocío A. Cornier, Patricia G. Mata, Ernesto G. Delpiccolo, Carina M.L. Boggián, Dora G. Del Giúdice, Antonela Mainetti, Leandro Ernesto Scharovsky, Olga Graciela Rozados, Viviana R. Rico, María José
author_facet	Giolito, Maria Virginia Camacho, Cristian M. Martinez-Amezaga, Maitena Traficante, Carla Inés Giordano, Rocío A. Cornier, Patricia G. Mata, Ernesto G. Delpiccolo, Carina M.L. Boggián, Dora G. Del Giúdice, Antonela Mainetti, Leandro Ernesto Scharovsky, Olga Graciela Rozados, Viviana R. Rico, María José
author_sort	Giolito, Maria Virginia
title	Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models
title_short	Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models
title_full	Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models
title_fullStr	Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models
title_full_unstemmed	Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models
title_sort	antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models
publisher	Future Science Group
publishDate	2020
url	http://hdl.handle.net/2133/19381 http://hdl.handle.net/2133/19381
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Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models

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