Lovastatin enhances in vitro radiation-induced apoptosis of rat B-cell lymphoma cells

Our previous demonstration of an antimetastatic effect of lovastatin, both in rat sarcoma and lymphoma tumor-models, as well as the fact that lovastatin and radiation are able to stop the cell cycle in different phases, suggested the feasibility of a combined treatment. We studied the effect of the...

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Autores principales: Rozados, Viviana R., Hinrichsen, Lucila Isabel, McDonnel, José, Scharovsky, O. Graciela
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: BioMed Central; "Regina Elena" National Cancer Institute, Italy 2012
Acceso en línea:http://hdl.handle.net/2133/1936
http://hdl.handle.net/2133/1936
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-1936
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv en
description Our previous demonstration of an antimetastatic effect of lovastatin, both in rat sarcoma and lymphoma tumor-models, as well as the fact that lovastatin and radiation are able to stop the cell cycle in different phases, suggested the feasibility of a combined treatment. We studied the effect of the in vitro combined treatment of a B-cell rat lymphoma (L-TACB) with lovastatin and irradiation. The results herein obtained provide new information about the role of statins as radiosensitizers. The antitumor effect of the combined treatment was higher than that elicited by either treatment alone. This effect could be a consequence, at least in part, of an enhanced apoptosis.
format article
artículo
publishedVersion
author Rozados, Viviana R.
Hinrichsen, Lucila Isabel
McDonnel, José
Scharovsky, O. Graciela
spellingShingle Rozados, Viviana R.
Hinrichsen, Lucila Isabel
McDonnel, José
Scharovsky, O. Graciela
Lovastatin enhances in vitro radiation-induced apoptosis of rat B-cell lymphoma cells
author_facet Rozados, Viviana R.
Hinrichsen, Lucila Isabel
McDonnel, José
Scharovsky, O. Graciela
author_sort Rozados, Viviana R.
title Lovastatin enhances in vitro radiation-induced apoptosis of rat B-cell lymphoma cells
title_short Lovastatin enhances in vitro radiation-induced apoptosis of rat B-cell lymphoma cells
title_full Lovastatin enhances in vitro radiation-induced apoptosis of rat B-cell lymphoma cells
title_fullStr Lovastatin enhances in vitro radiation-induced apoptosis of rat B-cell lymphoma cells
title_full_unstemmed Lovastatin enhances in vitro radiation-induced apoptosis of rat B-cell lymphoma cells
title_sort lovastatin enhances in vitro radiation-induced apoptosis of rat b-cell lymphoma cells
publisher BioMed Central; "Regina Elena" National Cancer Institute, Italy
publishDate 2012
url http://hdl.handle.net/2133/1936
http://hdl.handle.net/2133/1936
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AT mcdonneljose lovastatinenhancesinvitroradiationinducedapoptosisofratbcelllymphomacells
AT scharovskyograciela lovastatinenhancesinvitroradiationinducedapoptosisofratbcelllymphomacells
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