Achievements and challenges in the use of metronomics for the treatment of breast cancer

Two interesting therapeutic proposals for cancer treatment emerged at the beginning of the 21st century. The first one was metronomic chemotherapy, which refers to the chronic administration of chemotherapeutic agents, in low doses, without extended drug-free periods. Then, the idea of drug repositi...

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Autores principales:	Scharovsky, O. Graciela, Rico, María José, Mainetti, Leandro Ernesto, Perroud, Herman A, Rozados, Viviana R.
Formato:	article artículo publishedVersion
Lenguaje:	Español
Publicado:	Elsevier 2020
Materias:	Metronomic chemotherapy Drug repositioning Breast cancer Triple negative Preclinical-clinical
Acceso en línea:	http://hdl.handle.net/2133/19359 http://hdl.handle.net/2133/19359
Aporte de:	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario

id	I15-R121-2133-19359
record_format	dspace
institution	Universidad Nacional de Rosario
institution_str	I-15
repository_str	R-121
collection	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language	Español
orig_language_str_mv	spa
topic	Metronomic chemotherapy Drug repositioning Breast cancer Triple negative Preclinical-clinical
spellingShingle	Metronomic chemotherapy Drug repositioning Breast cancer Triple negative Preclinical-clinical Scharovsky, O. Graciela Rico, María José Mainetti, Leandro Ernesto Perroud, Herman A Rozados, Viviana R. Achievements and challenges in the use of metronomics for the treatment of breast cancer
topic_facet	Metronomic chemotherapy Drug repositioning Breast cancer Triple negative Preclinical-clinical
description	Two interesting therapeutic proposals for cancer treatment emerged at the beginning of the 21st century. The first one was metronomic chemotherapy, which refers to the chronic administration of chemotherapeutic agents, in low doses, without extended drug-free periods. Then, the idea of drug repositioning in oncology, the use of well-known drugs that were created for other uses to be utilized in oncology, gained strength. Shortly after, the two strategies were merged in one, named metronomics. Both approaches share several features which make metronomics an appealing choice for cancer treatment: use of known and approved drugs, thus diminishing the time necessary to enter to the clinic, therapeutic effect, low toxicity, oral administration, better life quality, low costs because of the use of, generally, out of patent drugs, possibility of use, even in countries with very low economic resources. Many chemotherapy and repurposed drugs were tested with metronomics approaches for the treatment of mammary cancer, the most common malignancy in women worldwide, leading to high rates of mortality. The wide range of therapeutic models studied, paralleled the wide range of responses obtained, like tumor growth and metastasis inhibition, overall survival increase, lack of toxicity, better life quality, among others. The accomplishments reached, and the challenges faced by researchers, are discussed.
format	article artículo publishedVersion
author	Scharovsky, O. Graciela Rico, María José Mainetti, Leandro Ernesto Perroud, Herman A Rozados, Viviana R.
author_facet	Scharovsky, O. Graciela Rico, María José Mainetti, Leandro Ernesto Perroud, Herman A Rozados, Viviana R.
author_sort	Scharovsky, O. Graciela
title	Achievements and challenges in the use of metronomics for the treatment of breast cancer
title_short	Achievements and challenges in the use of metronomics for the treatment of breast cancer
title_full	Achievements and challenges in the use of metronomics for the treatment of breast cancer
title_fullStr	Achievements and challenges in the use of metronomics for the treatment of breast cancer
title_full_unstemmed	Achievements and challenges in the use of metronomics for the treatment of breast cancer
title_sort	achievements and challenges in the use of metronomics for the treatment of breast cancer
publisher	Elsevier
publishDate	2020
url	http://hdl.handle.net/2133/19359 http://hdl.handle.net/2133/19359
work_keys_str_mv	AT scharovskyograciela achievementsandchallengesintheuseofmetronomicsforthetreatmentofbreastcancer AT ricomariajose achievementsandchallengesintheuseofmetronomicsforthetreatmentofbreastcancer AT mainettileandroernesto achievementsandchallengesintheuseofmetronomicsforthetreatmentofbreastcancer AT perroudhermana achievementsandchallengesintheuseofmetronomicsforthetreatmentofbreastcancer AT rozadosvivianar achievementsandchallengesintheuseofmetronomicsforthetreatmentofbreastcancer
bdutipo_str	Repositorios
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Achievements and challenges in the use of metronomics for the treatment of breast cancer

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