El género Brucella y su interacción con el sistema mononuclear fagocítico

Non-specific resistance is a fundamental component of the host immune response. The mononuclear phagocytic system (MPS) is part of innate resistance effector mechanisms, and is involved in several homeostatic, inflammatory and immunologic events. Mononuclear phagocytes (MNP), which are cells belon...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Arestegui, Mirta B., Gualtieri S., Catalina, Domínguez, Javier, Scharovsky, O. Graciela
Formato: article artículo publishedVersion
Lenguaje:Español
Publicado: Facultad de Veterinaria y Zootecnia-UNAM 2012
Materias:
mononuclear phagocytic system
macrophages
phagocytic
activity
genomic structure
cell mediated immunity
natural resistance
brucella spp
sistema mononuclear fagocítico
macrófagos
actividad
fagocítica
estructura genómica
inmunidad celular
resistencia natural
Acceso en línea:http://hdl.handle.net/2133/1924
http://hdl.handle.net/2133/1924
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-1924
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Español
orig_language_str_mv es
topic mononuclear phagocytic system
macrophages
phagocytic
activity
genomic structure
cell mediated immunity
natural resistance
brucella spp
sistema mononuclear fagocítico
macrófagos
actividad
fagocítica
estructura genómica
inmunidad celular
resistencia natural
spellingShingle mononuclear phagocytic system
macrophages
phagocytic
activity
genomic structure
cell mediated immunity
natural resistance
brucella spp
sistema mononuclear fagocítico
macrófagos
actividad
fagocítica
estructura genómica
inmunidad celular
resistencia natural
Arestegui, Mirta B.
Gualtieri S., Catalina
Domínguez, Javier
Scharovsky, O. Graciela
El género Brucella y su interacción con el sistema mononuclear fagocítico
topic_facet mononuclear phagocytic system
macrophages
phagocytic
activity
genomic structure
cell mediated immunity
natural resistance
brucella spp
sistema mononuclear fagocítico
macrófagos
actividad
fagocítica
estructura genómica
inmunidad celular
resistencia natural
description Non-specific resistance is a fundamental component of the host immune response. The mononuclear phagocytic system (MPS) is part of innate resistance effector mechanisms, and is involved in several homeostatic, inflammatory and immunologic events. Mononuclear phagocytes (MNP), which are cells belonging to the MPS, play a central role in the main functions of multicellular organisms. Its early interaction with pathogens determines the evolution of the infection. Bacteria, which can resist intracellular death, survive and multiply within the cells of the MPS, are considered endocellular parasites. Brucella genus that infects humans as well as several animal species is an endocellular pathogen. The vast majority of these microorganisms includes mechanisms genetically coded that enable them to invade and to survive within the host cells. In the present review, characteristics of Brucella genus are described; special reference is dedicated to its antigenic composition, virulence factors, as well as its genomic structure and the control of gene expression. Interaction between MPS and Brucella spp, and the effector mechanisms of MNP, mainly, plus the generation of oxygen and nitrogen radicals, the limitation in iron availability and cytokine production are analyzed. The control of infection is explained by cell mediated immunity and the phenomena of natural resistance is also taken into consideration.
format article
artículo
publishedVersion
author Arestegui, Mirta B.
Gualtieri S., Catalina
Domínguez, Javier
Scharovsky, O. Graciela
author_facet Arestegui, Mirta B.
Gualtieri S., Catalina
Domínguez, Javier
Scharovsky, O. Graciela
author_sort Arestegui, Mirta B.
title El género Brucella y su interacción con el sistema mononuclear fagocítico
title_short El género Brucella y su interacción con el sistema mononuclear fagocítico
title_full El género Brucella y su interacción con el sistema mononuclear fagocítico
title_fullStr El género Brucella y su interacción con el sistema mononuclear fagocítico
title_full_unstemmed El género Brucella y su interacción con el sistema mononuclear fagocítico
title_sort el género brucella y su interacción con el sistema mononuclear fagocítico
publisher Facultad de Veterinaria y Zootecnia-UNAM
publishDate 2012
url http://hdl.handle.net/2133/1924
http://hdl.handle.net/2133/1924
work_keys_str_mv AT aresteguimirtab elgenerobrucellaysuinteraccionconelsistemamononuclearfagocitico
AT gualtieriscatalina elgenerobrucellaysuinteraccionconelsistemamononuclearfagocitico
AT dominguezjavier elgenerobrucellaysuinteraccionconelsistemamononuclearfagocitico
AT scharovskyograciela elgenerobrucellaysuinteraccionconelsistemamononuclearfagocitico
bdutipo_str Repositorios
_version_ 1764820410532102145

Ejemplares similares