Biosynthesis of heme O in intraerythrocytic stages of Plasmodium falciparum and potential inhibitors of this pathway

A number of antimalarial drugs interfere with the electron transport chain and heme-related reactions; however, the biosynthesis of heme derivatives in Plasmodium parasites has not been fully elucidated. Here, we characterized the steps that lead to the farnesylation of heme. After the identificatio...

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Autores principales: Simão-Gurge, Raquel M., Wunderlich, Gerhard, Cricco, Julia Alejandra, Galindo Cubillos, Eliana F., Domenech-Carbó, Antonio, Cebrián-Torrejón, Gerardo, Almeida, Fernando G., Cirulli, Brenda Analía, Katzin, Alejandro M.
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: Springer Nature 2020
Materias:
Antimalarial drugs
Plasmodium parasites
Heme O synthesis
Plasmodium Falciparum
Inhibitors
Acceso en línea:http://hdl.handle.net/2133/18326
http://hdl.handle.net/2133/18326
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario

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